Vedilol 25 mg (Tablet)
Unit Price: ৳ 8.00 (2 x 10: ৳ 160.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Carvedilol |
| Company | Eskayef pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of mild, moderate, or severe heart failure
- Reduction of disease progression
- Use with digitalis, diuretics, and ACE inhibitor
- Use in patients unable to tolerate an ACE inhibitor
- Use in patients not receiving digitalis, hydralazine, or nitrate therapy
Pharmacology
- Non-selective antagonism of β-adrenergic receptors
- α-adrenergic antagonistic activity
- Antiproliferative properties
- Scavenger of reactive free oxidant radicals
- Used in hypertension, angina pectoris, and congestive heart failure
Dosage & Administration
- Initial dose of 12.5 mg once daily for hypertension
- Initial dose of 12.5 mg twice daily for angina pectoris
- Initial dose of 3.125 mg twice daily for heart failure
- Maximum daily dose of 50 mg for elderly patients
Interaction
- Increased levels of digoxin with concomitant use of Vedilol
- 60% decrease in Cmax and AUC with rifampin pretreatment
- No alteration of in vitro plasma protein binding of warfarin with Vedilol
- Potentiation of the pressor reaction with clonidine
Contraindications
- Decompensated heart failure requiring intravenous inotropic therapy
- Bronchial asthma or related bronchospastic conditions
- Second or third-degree AV block
- Sick sinus syndrome without a permanent pacemaker
- Cardiogenic shock or severe bradycardia
Side Effects
- Postural hypotension
- Dizziness
- Headache
- Fatigue
- Gastro-intestinal disturbances
- Bradycardia
- Peripheral oedema and painful extremities
- Dry mouth and eyes
- Impotence
- Disturbances of micturition
- Influenza-like symptoms
- Angina
- Allergic skin reactions
- Nasal stuffiness
- Depressed mood
Pregnancy & Lactation
- Not recommended during breast-feeding
- Not recommended during pregnancy
- Carvedilol crosses the placental barrier
Precautions & Warnings
- Caution in hepatic impairment
- Monitor clinical status for 2-3 hours after initiation and dose increases
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
- Beta-blockers
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children