Deflaza 24 mg (Tablet)

Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)
Strip Price: ৳ 300.00

Medicine Details

Indications

  • Anaphylaxis
  • Asthma
  • Rheumatoid arthritis
  • Juvenile chronic arthritis
  • Systemic lupus erythematosus
  • Dermatomyositis
  • Mixed connective tissue disease
  • Polyartritis nodosa
  • Sarcoidosis
  • Pemphigus
  • Bullous pemphigoid
  • Pyoderma gangrenosum
  • Minimal change nephrotic syndrome
  • Acute interstitial nephritis
  • Rheumatic carditis
  • Ulcerative colitis
  • Crohn's disease
  • Uveitis
  • Optic neuritis
  • Autoimmune haemolytic anaemia
  • Idiopathic thrombocytopenic purpura
  • Acute and lymphatic leukaemia
  • Malignant lymphoma
  • Multiple myeloma
  • Immune suppression in transplantation

Pharmacology

  • Anti-inflammatory action
  • Inhibition of Phospholipase A2 enzyme
  • Decrease in the release of certain immune system chemicals
  • Immunosuppressive action

Dosage & Administration

  • Adult dosage up to 120 mg/day for acute disorders
  • Maintenance doses in most conditions within the range of 3-18 mg/day
  • Smallest effective dose should be used for rheumatoid arthritis
  • High doses of 48-72 mg/day for bronchial asthma acute attack
  • Children dosage usually lies in the range 0.25-1.5 mg/kg/day
  • Alternate day administration may be appropriate
  • Guidance for juvenile chronic arthritis, nephrotic syndrome, and bronchial asthma doses

Interaction

  • Metabolized in the liver
  • Recommendation to increase maintenance dose if liver enzyme inducers are co-administered
  • Possibility to reduce maintenance dose for drugs which inhibit liver enzymes

Contraindications

  • Hypersensitivity to any of the ingredients
  • Patients receiving live virus immunization

Side Effects

  • GI disturbances
  • Musculoskeletal effects
  • Endocrine effects
  • Neuropsychiatric effects
  • Ophthalmic effects
  • Fluid and electrolyte disturbances
  • Susceptibility to infection
  • Impaired healing
  • Hypersensitivity reactions
  • Skin atrophy
  • Striae
  • Telangiectasia
  • Acne
  • Myocardial rupture following recent MI
  • Thromboembolism

Pregnancy & Lactation

  • Crosses the placenta
  • Potential risk of intrauterine growth retardation with prolonged or repeated use during pregnancy
  • Excretion in breast milk
  • Unlikely systemic effects in the infant with doses up to 50 mg daily

Precautions & Warnings

  • Special caution for cardiac disease or congestive heart failure
  • Necessity for patient monitoring in various clinical conditions
  • Potential salt and water retention
  • Increased excretion of potassium
  • Dietary salt restriction and potassium supplementation may be necessary
  • Caution in gastritis, oesophagitis, diverticulitis, ulcerative colitis
  • Special caution in diabetes mellitus, osteoporosis, myasthenia gravis, renal insufficiency
  • Caution in emotional instability, psychotic tendency, epilepsy
  • Previous corticosteroid-induced myopathy
  • Attention in liver failure, hypothyroidism, and cirrhosis
  • Special caution for ocular herpes simplex

Use in Special Populations

  • Increased monitoring and dosage adjustment in hepatic impairment
  • No special precautions for renally impaired patients
  • No special precautions for the elderly

Therapeutic Class

  • Glucocorticoids

Storage Conditions

  • Cool and dry place below 25°C
  • Protected from light and moisture
  • Keep out of the reach of children

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