Deflaza 24 mg (Tablet)
Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)
Strip Price: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Deflazacort |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Anaphylaxis
- Asthma
- Rheumatoid arthritis
- Juvenile chronic arthritis
- Systemic lupus erythematosus
- Dermatomyositis
- Mixed connective tissue disease
- Polyartritis nodosa
- Sarcoidosis
- Pemphigus
- Bullous pemphigoid
- Pyoderma gangrenosum
- Minimal change nephrotic syndrome
- Acute interstitial nephritis
- Rheumatic carditis
- Ulcerative colitis
- Crohn's disease
- Uveitis
- Optic neuritis
- Autoimmune haemolytic anaemia
- Idiopathic thrombocytopenic purpura
- Acute and lymphatic leukaemia
- Malignant lymphoma
- Multiple myeloma
- Immune suppression in transplantation
Pharmacology
- Anti-inflammatory action
- Inhibition of Phospholipase A2 enzyme
- Decrease in the release of certain immune system chemicals
- Immunosuppressive action
Dosage & Administration
- Adult dosage up to 120 mg/day for acute disorders
- Maintenance doses in most conditions within the range of 3-18 mg/day
- Smallest effective dose should be used for rheumatoid arthritis
- High doses of 48-72 mg/day for bronchial asthma acute attack
- Children dosage usually lies in the range 0.25-1.5 mg/kg/day
- Alternate day administration may be appropriate
- Guidance for juvenile chronic arthritis, nephrotic syndrome, and bronchial asthma doses
Interaction
- Metabolized in the liver
- Recommendation to increase maintenance dose if liver enzyme inducers are co-administered
- Possibility to reduce maintenance dose for drugs which inhibit liver enzymes
Contraindications
- Hypersensitivity to any of the ingredients
- Patients receiving live virus immunization
Side Effects
- GI disturbances
- Musculoskeletal effects
- Endocrine effects
- Neuropsychiatric effects
- Ophthalmic effects
- Fluid and electrolyte disturbances
- Susceptibility to infection
- Impaired healing
- Hypersensitivity reactions
- Skin atrophy
- Striae
- Telangiectasia
- Acne
- Myocardial rupture following recent MI
- Thromboembolism
Pregnancy & Lactation
- Crosses the placenta
- Potential risk of intrauterine growth retardation with prolonged or repeated use during pregnancy
- Excretion in breast milk
- Unlikely systemic effects in the infant with doses up to 50 mg daily
Precautions & Warnings
- Special caution for cardiac disease or congestive heart failure
- Necessity for patient monitoring in various clinical conditions
- Potential salt and water retention
- Increased excretion of potassium
- Dietary salt restriction and potassium supplementation may be necessary
- Caution in gastritis, oesophagitis, diverticulitis, ulcerative colitis
- Special caution in diabetes mellitus, osteoporosis, myasthenia gravis, renal insufficiency
- Caution in emotional instability, psychotic tendency, epilepsy
- Previous corticosteroid-induced myopathy
- Attention in liver failure, hypothyroidism, and cirrhosis
- Special caution for ocular herpes simplex
Use in Special Populations
- Increased monitoring and dosage adjustment in hepatic impairment
- No special precautions for renally impaired patients
- No special precautions for the elderly
Therapeutic Class
- Glucocorticoids
Storage Conditions
- Cool and dry place below 25°C
- Protected from light and moisture
- Keep out of the reach of children