Eval CR 200 mg (Tablet (Controlled Release))

Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Sodium valproate
Company Unimed unihealth pharmaceuticals ltd
Also available as
Eval 250 mg syrup Eval 250 mg tablet Eval cr 300 mg tablet Eval cr 500 mg tablet

Indications

  • Treatment of all types of epilepsy
  • Treatment of bipolar disorder
  • Prophylaxis of migraine

Composition

  • Sodium Valproate tablet: Each enteric-coated tablet contains Sodium Valproate BP 200 mg
  • Sodium Valproate syrup: Each 5 ml syrup contains Sodium Valproate BP 200 mg
  • Sodium Valproate controlled release 200 tablet: Each enteric-coated controlled release tablet contains Sodium Valproate 200 mg as Sodium Valproate BP 133.2 mg & Valproic acid BP 58 mg
  • Sodium Valproate controlled release 300 tablet: Each enteric-coated controlled release tablet contains Sodium Valproate 300 mg as Sodium Valproate BP 199.8 mg & Valproic acid BP 87 mg
  • Sodium Valproate controlled release 500 tablet: Each enteric-coated controlled release tablet contains Sodium Valproate 500 mg as Sodium Valproate BP 333 mg & Valproic acid BP 145 mg
  • Sodium Valproate injection: Each 5 ml injectable solution contains Sodium Valproate BP eqv. to Valproic Acid 500 mg

Pharmacology

Anti-epileptic activity against a variety of seizures

Dosage & Administration

  • Oral:
    • May be given once or twice daily
    • May be given in divided doses
  • Epilepsy:
    • Adult: Initial dose is 600 mg daily, increasing to a maximum of 2.5 g daily in divided doses
    • Children (over 20 kg): Initially 400 mg daily, increased until control
    • Children (up to 20 kg): Initially 20 mg/kg daily
  • Bipolar disorder:
    • Initially 600 mg daily
    • Maintenance dosage is 1000-2000 mg daily
  • Prophylaxis of migraine: 400-600 mg daily, some may require 1000-1500 mg daily
  • Injection:
    • Adults: Usually 400-800 mg depending on body weight, followed by continuous or repeated infusion
    • Children: Initial: 20-30 mg/kg/day, Maximum: 40 mg/kg/day

Interaction

Acts as a non-specific inhibitor of drug metabolism

Contraindications

  • Known hypersensitivity
  • Liver dysfunction
  • Restricted during pregnancy and in women of childbearing potential

Side Effects

  • Common:
    • Anorexia
    • Nausea
    • Vomiting
  • CNS:
    • Sedation
    • Ataxia
    • Tremor
  • Hepatic function:
    • Elevation of liver enzymes in plasma
    • Fulminate hepatitis
    • Acute pancreatitis
    • Hyperammonemia

Pregnancy & Lactation

  • Pregnancy: Associated with neural tube defects
  • Lactation: Excreted in breast milk

Precautions & Warnings

  • Liver function monitoring
  • No undue potential for bleeding
  • Care in renal impairment
  • Avoid sudden withdrawal of therapy

Therapeutic Class

Primary anti-epileptic drugs

Storage Conditions

Do not store above 30°C, Keep away from light and out of the reach of children

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