Eval CR 300 mg (Tablet (Controlled Release))

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Sodium valproate
Company Unimed unihealth pharmaceuticals ltd
Also available as
Eval 250 mg syrup Eval 250 mg tablet Eval cr 200 mg tablet Eval cr 500 mg tablet

Indications

  • Treatment of all types of epilepsy
  • Prophylaxis of febrile convulsion
  • Prophylaxis of post-traumatic epilepsy
  • Treatment of bipolar disorder
  • Prophylaxis of migraine

Composition

  • Enteric-coated tablets with Sodium Valproate BP 200 mg
  • Syrup with Sodium Valproate BP 200 mg per 5 ml
  • Controlled release tablets with different strengths of Sodium Valproate and Valproic acid
  • Injectable solution with Sodium Valproate BP equivalent to Valproic Acid 500 mg per 5 ml

Pharmacology

  • Sodium Valproate endowed with anti-epileptic activity
  • Mechanism of action possibly related to increased brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

  • Oral administration for epilepsy, bipolar disorder, and prophylaxis of migraine
  • Initial and maintenance doses for adults and children
  • Injection dosage for adults and children
  • Recommendation to administer after food

Interaction

  • Non-specific inhibitor of drug metabolism
  • Significant interactions with Phenobarbital, Phenytoin, Warfarin, Aspirin, etc.

Contraindications

  • Known hypersensitivity to the drug
  • Liver dysfunction
  • Restricted use during pregnancy and in women of childbearing potential

Side Effects

  • Common side effects like anorexia, nausea, and vomiting
  • Effects minimized with enteric-coated tablets
  • CNS effects including sedation, ataxia, and tremor
  • Rare occurrence of rash, alopecia, and stimulation of appetite
  • Elevation of liver enzymes observed in up to 40% of patients
  • Potential for fulminate hepatitis, acute pancreatitis, and hyperammonemia

Pregnancy & Lactation

  • Crosses the placenta
  • Associated with neural tube defects in newborn if exposed during the first trimester
  • Excreted in breast milk with no significant risk to the child

Precautions & Warnings

  • Monitoring of liver functions before therapy and during the first 6 months
  • No undue potential for bleeding before major surgery
  • Care in renal impairment, pregnancy, and breast-feeding
  • Elimination in urine may lead to false interpretation of urine ketone test
  • Sudden withdrawal should be avoided

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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