Eval CR 500 mg (Tablet (Controlled Release))

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Sodium valproate
Company Unimed unihealth pharmaceuticals ltd
Also available as
Eval 250 mg syrup Eval 250 mg tablet Eval cr 200 mg tablet Eval cr 300 mg tablet

Indications

  • Treatment of all types of epilepsy
  • Prophylaxis of febrile convulsion
  • Prophylaxis of post-traumatic epilepsy
  • Treatment of bipolar disorder
  • Prophylaxis of migraine

Composition

  • Sodium Valproate tablet: 200mg
  • Sodium Valproate syrup: 200mg in 5ml
  • Sodium Valproate controlled release 200 tablet: 200mg
  • Sodium Valproate controlled release 300 tablet: 300mg
  • Sodium Valproate controlled release 500 tablet: 500mg
  • Sodium Valproate injection: 500mg in 5ml

Pharmacology

  • Endowed with anti-epileptic activity
  • Mechanism may relate to increased brain levels of GABA

Dosage & Administration

  • Tablets may be given once or twice daily
  • Syrup should be given in divided doses
  • Dosage varies for epilepsy, bipolar disorder, and prophylaxis of migraine
  • Injection dosage varies for adults and children

Interaction

  • Acts as a non specific inhibitor of drug metabolism
  • Significant interactions with Phenobarbital, Phenytoin, Warfarin, Aspirin

Contraindications

  • Known hypersensitivity to the drug
  • Liver dysfunction
  • Use restricted during pregnancy and in women of childbearing potential

Side Effects

  • Common side effects like anorexia, nausea, vomiting, minimized with enteric coated tablets
  • Effects on CNS include sedation, ataxia, tremor
  • Rarely rash, alopecia, stimulation of appetite
  • Elevation of liver enzymes in plasma observed in up to 40% of patients
  • Fulminate hepatitis rarely
  • Hepatic injury, acute pancreatitis, and hyperammonemia in children and those on multiple antiepileptic agents

Pregnancy & Lactation

  • Crosses the placenta
  • Exposure in first trimester associated with neural tube defects
  • Excreted in breast milk
  • Breast-feeding probably causes no risk to the child

Precautions & Warnings

  • Monitor liver functions before and during therapy
  • Ensure no potential for bleeding before major surgery
  • Take care in renal impairment, pregnancy, breast-feeding, systemic lupus erythematosus
  • Ketone metabolite elimination may lead to false interpretation of urine ketone test
  • Avoid sudden withdrawal of therapy

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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