Ondan 8 mg (Tablet)
Unit Price: ৳ 11.00 (3 x 10: ৳ 330.00)
Strip Price: ৳ 110.00
Medicine Details
Category | Details |
---|---|
Generic | Ondansetron |
Company | Unimed unihealth pharmaceuticals ltd |
Also available as |
Title
- Ondan Tablet
- Ondan Oral Soluble Film
- Ondansetron Oral Solution
Category
- Medicine
- Anti-emetic drugs
Description
- Orally dissolving film
- Serotonin subtype 3 (5-HT3) receptor antagonist
- Selective blocking agent
- Racemic form of Ondan
- Empirical formula C18H19N3O
- Molecular weight of 293.3
Indications
- Prevention of nausea and vomiting associated with emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Pharmacology
- Potent and highly selective 5HT3 receptor-antagonist
- Precise mode of action not fully known
- Blocks 5HT3 receptors in peripheral and central nervous system
Dosage
- Adult dosage
- Pediatric dosage
- Chemotherapy-induced Nausea and Vomiting dosage
- Radiotherapy-induced Nausea and Vomiting dosage
- Postoperative Nausea and Vomiting dosage
- Dosage adjustment for renal function
- Dosage adjustment for hepatic function
- Dosage in special populations (age and hepatic function)
Administration
- Oral soluble film administration steps
- Dissolves on top of the tongue within 20 seconds
- Does not require water for dissolution or swallowing
Interaction
- Metabolized by hepatic cytochrome P-450
- Effects of inducers or inhibitors may change clearance and half-life
Contraindications
- Hypersensitivity to the drug or its components
- Concomitant use of apomorphine
Side Effects
- Headache
- Constipation
- Diarrhea
- Rash
- Sensation of flushing or warmth
- Hiccups
- Liver enzyme abnormalities
- Anaphylaxis
- Brochospasm
- Tachycardia
- Angina
- Hypokalemia
- Shortness of breath
- No evidence of extrapyramidal reactions
- Oculogyric crisis
- Rates of events not significantly different from placebo in some cases
Pregnancy & Lactation
- No evidence of carcinogenic effects in animal studies
- Not mutagenic
- Did not affect fertility or general reproduction performance in animal studies
- Caution advised during breastfeeding
Precautions & Warnings
- Reported hypersensitivity reactions
- Not a drug that stimulates gastric or intestinal peristalsis
- Not a substitute for nasogastric suction
- Caution in patients following abdominal surgery or with chemotherapy-induced nausea and vomiting
Use in Special Populations
- Dosage adjustment for renal function
- Dosage adjustment for hepatic function
- Little information available for pediatric patients 4 years of age or younger
- No dosage adjustment needed for patients over the age of 65
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Dry place
- Protect from light and moisture