Ondan 8 mg (Tablet)

Unit Price: ৳ 11.00 (3 x 10: ৳ 330.00)
Strip Price: ৳ 110.00

Medicine Details

Title

  • Ondan Tablet
  • Ondan Oral Soluble Film
  • Ondansetron Oral Solution

Category

  • Medicine
  • Anti-emetic drugs

Description

  • Orally dissolving film
  • Serotonin subtype 3 (5-HT3) receptor antagonist
  • Selective blocking agent
  • Racemic form of Ondan
  • Empirical formula C18H19N3O
  • Molecular weight of 293.3

Indications

  • Prevention of nausea and vomiting associated with emetogenic cancer chemotherapy
  • Prevention and treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Pharmacology

  • Potent and highly selective 5HT3 receptor-antagonist
  • Precise mode of action not fully known
  • Blocks 5HT3 receptors in peripheral and central nervous system

Dosage

  • Adult dosage
  • Pediatric dosage
  • Chemotherapy-induced Nausea and Vomiting dosage
  • Radiotherapy-induced Nausea and Vomiting dosage
  • Postoperative Nausea and Vomiting dosage
  • Dosage adjustment for renal function
  • Dosage adjustment for hepatic function
  • Dosage in special populations (age and hepatic function)

Administration

  • Oral soluble film administration steps
  • Dissolves on top of the tongue within 20 seconds
  • Does not require water for dissolution or swallowing

Interaction

  • Metabolized by hepatic cytochrome P-450
  • Effects of inducers or inhibitors may change clearance and half-life

Contraindications

  • Hypersensitivity to the drug or its components
  • Concomitant use of apomorphine

Side Effects

  • Headache
  • Constipation
  • Diarrhea
  • Rash
  • Sensation of flushing or warmth
  • Hiccups
  • Liver enzyme abnormalities
  • Anaphylaxis
  • Brochospasm
  • Tachycardia
  • Angina
  • Hypokalemia
  • Shortness of breath
  • No evidence of extrapyramidal reactions
  • Oculogyric crisis
  • Rates of events not significantly different from placebo in some cases

Pregnancy & Lactation

  • No evidence of carcinogenic effects in animal studies
  • Not mutagenic
  • Did not affect fertility or general reproduction performance in animal studies
  • Caution advised during breastfeeding

Precautions & Warnings

  • Reported hypersensitivity reactions
  • Not a drug that stimulates gastric or intestinal peristalsis
  • Not a substitute for nasogastric suction
  • Caution in patients following abdominal surgery or with chemotherapy-induced nausea and vomiting

Use in Special Populations

  • Dosage adjustment for renal function
  • Dosage adjustment for hepatic function
  • Little information available for pediatric patients 4 years of age or younger
  • No dosage adjustment needed for patients over the age of 65

Therapeutic Class

  • Anti-emetic drugs

Storage Conditions

  • Store at temperature not exceeding 30°C
  • Dry place
  • Protect from light and moisture

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