Benz 400 mg (Chewable Tablet)

Unit Price: ৳ 3.20 (50's pack: ৳ 160.00)

Medicine Details

Category	Details
Generic	Albendazole
Company	Belsen pharmaceuticals ltd

Benz is indicated in single and mixed infestations of Hookworm (Ancylostoma, Necator), Roundworm (Ascaris), Threadworm (Enterobius), Whipworm (Trichuris), Strongyloides, Tapeworm, Opisthorchi, Hydatid.

Benz is a benzimidazole anthelmintic, active against most nematodes and some cestodes. It is used in the treatment of intestinal nematode infections and in higher doses in the treatment of hydatid disease. Benz exhibits vermicidal, ovicidal, and larvicidal activity. The principal mode of action of Benz is its inhibitory effect on tubulin polymerization, which results in the loss of cytoplasmic microtubules.

Albendazole is a broad spectrum anthelmintic. Albendazole exhibits vermicidal, ovicidal and larvicidal activities. The drug is thought to exert its anthelmintic effect by blocking glucose uptake in the susceptible helminths, thereby depleting the energy level until it becomes inadequate for survival. Immobilization is followed by the parasite.

Adults & children over 2 years: 400 mg (1 tablet or 10 ml suspension) as a single dose in cases of various infections. In cases of strongyloidiasis or taeniasis, 400 mg (1 tablet or 10 ml suspension) daily should be given for 3 consecutive days. Children of 1-2 years: Recommended dose is a single dose of 200 mg. Children under 1 year: Not recommended. In Hydatid disease (Echinococcosis): Albendazole is given by mouth with meals in a dose of 400 mg twice daily for 28 days for patients weighing over 60 kg.

No interaction involving Benz, either pharmacodynamic or pharmacokinetic, has been reported.

Neonates: Albendazole is not normally used in neonates. Children: Reduction of the dose from 400 mg to 200 mg may be indicated in children weighing less than 10 kg but there are no grounds for a general reduction in dosage to children. Pregnant woman: Albendazole should not be given during pregnancy or women thought to be pregnant. Concurrent disease: There is no evidence to suggest that dose should be altered in renal, hepatic or cardiac failure.

Gastrointestinal disturbances, headache, dizziness, changes in liver enzymes, rarely reversible alopecia; rash, fever, blood disorders including leucopenia and pancytopenia reported; allergic shock if cyst leakage; convulsion and meningism in cerebral disease.

US FDA Pregnancy category of Albendazole is C. So, Albendazole should be avoided in pregnancy and lactation unless the potential benefits outweigh the possible risks to the fetus.

Blood counts and liver function tests before treatment and twice during each cycle; breastfeeding; exclude pregnancy before starting treatment. Benz should only be used in the treatment of Echinococcosis if there is constant medical supervision with regular monitoring of serum-transaminase concentrations and of leucocyte and platelet counts.

Keep in a dry place, away from light and heat. Keep out of the reach of children.