Angist SR 2.6 mg (Tablet (Sustained Release))

Indications

• Prophylaxis of angina pectoris
• Not useful in aborting an acute anginal episode

Pharmacology

• Causes relaxation of vascular smooth muscle
• Produces vasodilator effect on peripheral arteries and veins
• Reduces left ventricular end-diastolic pressure
• Reduces systemic vascular resistance and arterial pressure

Dosage & Administration

• Dosage should be adjusted according to individual patient requirements and response
• One 2.6 mg sustained released tablet or capsule in morning and evening for adults
• Should be taken on an empty stomach

Interaction

• May increase antihypertensive properties of vasodilators, calcium antagonists, beta-adrenergic blockers
• Concomitant use with tricyclic antidepressants and alcohol may cause high blood pressure
• Concomitant use with phosphodiesterase type 5 (PDE5) inhibitors may cause fall in blood pressure
• Aspirin decreases the clearance and enhances the hemodynamic effects
• May reduce the pharmacologic effects of heparin
• Increases the bioavailability of dihydroergotamine

Contraindications

• Known hypersensitivity to nitroglycerin, other organic nitrates, or nitrites
• Acute myocardial infarction
• Marked anaemia
• Head trauma
• Cerebral haemorrhage
• Closed angle glaucoma

Side Effects

• Headache (at the onset of treatment)
• Tachycardia
• Postural hypotension and syncope
• Cyanosis
• Methaemoglobinaemia

Pregnancy & Lactation

• No evidence on safety in pregnancy and lactation
• Should be administered to pregnant women and nursing mothers only if considered essential by the physician

Precautions & Warnings

• Use with caution in patients predisposed to closed-angle glaucoma
• Abrupt discontinuation may lead to exacerbation of symptoms
• Dosage should be reduced gradually over several days when discontinuing long term treatment
• Particular attention required during early days of acute myocardial infarction

Overdose Effects

• Peripheral vasodilation with a fall in blood pressure
• Reflex tachycardia
• Monitoring of cardiac function and supportive measures required
• Circulating plasma volume should be increased by substitution of fluid
• Consideration of vasopressors in life-threatening situations

Therapeutic Class

• Nitrates: Coronary vasodilators

Storage Conditions

• Store in a cool and dry place away from light and heat
• Keep out of the reach of children

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