Celbarin 200 mg (Capsule)
Unit Price: ৳ 35.00 (2 x 10: ৳ 700.00)
Strip Price: ৳ 350.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ribavirin |
| Company | Incepta pharmaceuticals ltd |
Indications
- Treatment of chronic hepatitis C (CHC)
- Combination therapy with other antiviral drugs
- Patients with compensated liver disease
- Adult CHC patients coinfected with HIV
Pharmacology
- Inhibitory action against respiratory syncytial virus
- Inhibitory action against influenza virus
- Inhibitory action against herpes simplex virus
- Mechanism of action not clear
- Interference with viral nucleic acid synthesis
Dosage & Administration
- Recommended treatment duration of 24 to 48 weeks
- Assessment of virologic response after 24 weeks
- Consideration of treatment discontinuation if HCV RNA not below the limit of detection by 24 weeks
- No safety and efficacy data for treatment longer than 48 weeks
- No safety and efficacy data for treatment longer than 24 weeks in relapse patient populations
Interaction
- Potential interactions with nucleoside reverse transcriptase inhibitors
- Potential interactions with azathioprine
Contraindications
- Contraindicated in pregnant women
- Risk of fetal harm
- Contraindicated in patients with hemoglobinopathies
- Contraindicated in combination with didanosine
Side Effects
- Psychiatric and central nervous system effects
- Severe ocular disorder
- Dental and periodontal disorders
- Growth inhibition in children and adolescents
- Irreversible growth inhibition in some patients
Pregnancy & Lactation
- Pregnancy Category X
- Significant embryocidal and teratogenic effects in animal studies
- Unknown excretion in human milk
- Consideration of discontinuing nursing
Precautions & Warnings
- Avoid use in pregnancy and for 6 months after treatment
- Requirement for negative pregnancy test prior to therapy
- Requirement for use of contraception and monthly pregnancy tests
- Importance for male patients' partners to avoid becoming pregnant
- Avoidance of sex with pregnant women
Use in Special Populations
- Safety and effectiveness not established in pediatric patients below 3 years
- Greater risk of toxic reactions in patients with impaired renal function
- Dose adjustment for patients with creatinine clearance
Therapeutic Class
- Hepatic viral infections (Hepatitis C)
Storage Conditions
- Keep out of the reach of children
- Keep in a cool and dry place
- Protection from light