Anril 400 mcg/spray (Topical Spray)

200 metered spray: ৳ 270.00

Medicine Details

Category Details
Generic Nitroglycerin sublingual spray
Company Square pharmaceuticals plc

Indications

  • Acute relief of angina pectoris
  • Prophylaxis of angina pectoris

Description

  • Organic nitrate vasodilator
  • Metered dose spray
  • 400 mcg per spray
  • 200 metered sprays
  • Spray droplets under the tongue

Pharmacology

  • Relaxation of vascular smooth muscle
  • Vasodilator effect on arteries and veins
  • Reduces left ventricular enddiastolic pressure
  • Reduces systemic vascular resistance

Dosage

  • 1-2 metered sprays at onset of attack
  • Maximum 3 metered sprays in 15 minutes
  • Prophylactic use 5-10 minutes prior to activity

Administration

  • Carry at all times
  • Not for routine use
  • Avoid alcohol consumption
  • Avoid sildenafil, vardenafil, or tadalafil
  • Keep away from children
  • Sit down during angina attack
  • Do not shake container
  • Administer under the tongue
  • Avoid swallowing immediately after administering

Interaction

  • Severe hypotension with alcohol use
  • Enhanced bioavailability of dihydroergotamine
  • Orthostatic hypotension with specific drug combinations

Contraindications

  • Hypersensitivity to nitrates
  • Hypotension, hypovolaemia, severe anaemia
  • Cerebral haemorrhage and brain trauma
  • Mitral stenosis and hypertrophic obstructive cardiomyopathy
  • Concomitant use of phosphodiesterase inhibitors

Side Effects

  • Headache
  • Facial flushing
  • Dizziness
  • Nausea
  • Vomiting
  • Weakness
  • Postural hypotension
  • Reflex tachycardia

Pregnancy & Lactation

  • Pregnancy Category C
  • Caution during nursing

Precautions & Warnings

  • Attention during acute myocardial infarction
  • Caution in patients with impaired renal or hepatic function, hypothyroidism, malnutrition, or hypothermia

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients

Overdose Effects

  • Symptoms of severe hypotension
  • Headache
  • Vertigo
  • Palpitation
  • Visual disturbance
  • Flushing and perspiring skin
  • Nausea and vomiting
  • Syncope
  • Methemoglobinemia
  • Treatment includes recumbent position, oxygen administration, and methylene blue if necessary

Therapeutic Class

  • Nitrates: Coronary vasodilators

Storage Conditions

  • Cool and dry place away from light and heat

Related Brands