Anril 400 mcg/spray (Topical Spray)

Indications

• Acute relief of angina pectoris
• Prophylaxis of angina pectoris

Description

• Organic nitrate vasodilator
• Metered dose spray
• 400 mcg per spray
• 200 metered sprays
• Spray droplets under the tongue

Pharmacology

• Relaxation of vascular smooth muscle
• Vasodilator effect on arteries and veins
• Reduces left ventricular enddiastolic pressure
• Reduces systemic vascular resistance

Dosage

• 1-2 metered sprays at onset of attack
• Maximum 3 metered sprays in 15 minutes
• Prophylactic use 5-10 minutes prior to activity

Administration

• Carry at all times
• Not for routine use
• Avoid alcohol consumption
• Avoid sildenafil, vardenafil, or tadalafil
• Keep away from children
• Sit down during angina attack
• Do not shake container
• Administer under the tongue
• Avoid swallowing immediately after administering

Interaction

• Severe hypotension with alcohol use
• Enhanced bioavailability of dihydroergotamine
• Orthostatic hypotension with specific drug combinations

Contraindications

• Hypersensitivity to nitrates
• Hypotension, hypovolaemia, severe anaemia
• Cerebral haemorrhage and brain trauma
• Mitral stenosis and hypertrophic obstructive cardiomyopathy
• Concomitant use of phosphodiesterase inhibitors

Side Effects

• Headache
• Facial flushing
• Dizziness
• Nausea
• Vomiting
• Weakness
• Postural hypotension
• Reflex tachycardia

Pregnancy & Lactation

• Pregnancy Category C
• Caution during nursing

Precautions & Warnings

• Attention during acute myocardial infarction
• Caution in patients with impaired renal or hepatic function, hypothyroidism, malnutrition, or hypothermia

Use in Special Populations

• Safety and effectiveness not established in pediatric patients

Overdose Effects

• Symptoms of severe hypotension
• Headache
• Vertigo
• Palpitation
• Visual disturbance
• Flushing and perspiring skin
• Nausea and vomiting
• Syncope
• Methemoglobinemia
• Treatment includes recumbent position, oxygen administration, and methylene blue if necessary

Therapeutic Class

• Nitrates: Coronary vasodilators

Storage Conditions

• Cool and dry place away from light and heat

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