Isentin M 2.5 mg+500 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for glycemic control in adults with type 2 diabetes mellitus
Pharmacology
- DPP-4 inhibitor
- GLP-1 and GIP hormone incretin enhancer
- Reduces glucagon secretion
- Lowers basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Immediate release tablet
- Extended release tablet
- Individualized dosage based on effectiveness and tolerability
- Gradual dose escalation to reduce gastrointestinal side effects
- Recommended starting dose for new and existing patients
Cationic Drugs
- Potential interaction with Metformin
- Recommendation for careful patient monitoring and dose adjustment
Carbonic Anhydrase Inhibitors
- May induce metabolic acidosis
- Use with caution in patients taking Isentin M
Inducers of P-glycoprotein and CYP3A4 Enzymes
- Impacts Linagliptin exposure
- Recommended use of alternative treatments
Drugs Affecting Glycemic Control
- May lead to loss of glycemic control
- Caution and close observation required in combination with Isentin M
Contraindications
- Renal impairment
- Acute or chronic metabolic acidosis
- Hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Most common: nasopharyngitis and diarrhea
- Increased risk of hypoglycemia with Isentin M and sulfonylureas
Pregnancy & Lactation
- Caution advised in pregnancy and lactation due to limited studies
Precautions & Warnings
- Prone to lactic acidosis and acute pancreatitis
- Need for temporary discontinuation during certain medical procedures
- Monitoring of Vitamin B12 levels
- Recommendations for alcohol consumption, other medicines, counseling, travel, and emergency preparedness
- Potential for hypoglycemia
Overdose Effects
- Supportive measures in event of overdose
- Dialyzable properties of Metformin Hydrochloride
- No dose-related clinical adverse drug reactions for Linagliptin up to 600mg
- Reported hypoglycemia and lactic acidosis in Metformin Hydrochloride overdose
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of reach of children