Nebiren 2.5 mg (Tablet)

Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Nebivolol hydrochloride
Company Renata limited
Also available as
Nebiren 5 mg tablet

Indications

  • Hypertension
  • Treatment of essential hypertension
  • Chronic heart failure (CHF)
  • Treatment of stable mild and moderate chronic heart failure in elderly patients

Pharmacology

  • β adrenergic receptor blocking agent
  • Inhibition of β1 and β1 adrenergic receptors
  • Lack of intrinsic sympathomimetic and membrane stabilizing activity
  • Decreased heart rate
  • Decreased myocardial contractility
  • Diminution of tonic sympathetic outflow to the periphery from cerebral vasomotor centers
  • Suppression of renin activity
  • Vasodilation and decreased peripheral vascular resistance
  • Metabolism by glucuronidation and hydroxylation by CYP2D6
  • Plasma protein binding of approximately 98%
  • Absorption similar to an oral solution
  • Metabolism via direct glucuronidation, N-dealkylation, and oxidation via cytochrome P450 2D6
  • Excretion via urine and feces
  • No significant interaction with digoxin or warfarin
  • Starting dose reduction in patients with moderate hepatic impairment

Dosage & Administration

  • Recommended starting dose of 5 mg once daily
  • Dose can be increased at 2-week intervals up to 40 mg
  • No benefit from more frequent dosing regimen

Interaction

  • Caution with myocardial depressants or inhibitors of AV conduction
  • Avoid combining with other β-blockers
  • Closely monitor patients receiving catecholamine-depleting drugs

Contraindications

  • Severe bradycardia
  • Heart block greater than first degree
  • Cardiogenic shock
  • Decompensated cardiac failure
  • Sick sinus syndrome without a permanent pacemaker
  • Severe hepatic impairment
  • Hypersensitivity to any component of the product

Side Effects

  • Headache
  • Nausea
  • Bradycardia

Precautions & Warnings

  • Caution against abrupt discontinuation of therapy
  • Cautious administration in patients with compensated congestive heart failure
  • Not studied in patients with angina pectoris or recent MI
  • Patients with bronchospastic diseases should not receive β-blockers
  • Closely monitor perioperative use
  • Caution in diabetic patients and those with hypoglycemia
  • Monitoring for signs of hyperthyroidism
  • Exercise caution in patients with peripheral vascular disease
  • Monitor patients treated concomitantly with non-dihydropyridine calcium channel blockers

Use in Special Populations

  • Use with caution in patients with severe renal impairment
  • Use with caution in patients with moderate hepatic impairment
  • Contradicted in patients with severe hepatic impairment
  • Higher reactivity to repeated challenges for patients with a history of severe anaphylactic reactions to various allergens
  • No studies in patients receiving dialysis

Therapeutic Class

  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep below 30°C temperature
  • Keep away from light & moisture
  • Keep out of the reach of children

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