Deflazit 6 mg/5 ml (Oral Suspension)
50 ml bottle: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Deflazacort |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Anaphylaxis
- Asthma
- Rheumatoid arthritis
- Juvenile chronic arthritis
- Systemic lupus erythematosus
- Dermatomyositis
- Mixed connective tissue disease
- Polyartritis nodosa
- Sarcoidosis
- Pemphigus
- Bullous pemphigoid
- Pyoderma gangrenosum
- Minimal change nephrotic syndrome
- Acute interstitial nephritis
- Rheumatic carditis
- Ulcerative colitis
- Crohn's disease
- Uveitis
- Optic neuritis
- Autoimmune haemolytic anaemia
- Idiopathic thrombocytopenic purpura
- Acute and lymphatic leukaemia
- Malignant lymphoma
- Multiple myeloma
- Immune suppression in transplantation
Pharmacology
- Anti-inflammatory action
- Inhibition of Phospholipase A2 enzyme
- Prostaglandin synthesis inhibition
- Immunosuppressive action
Dosage & Administration
- Adult dosage up to 120 mg/day for acute disorders
- Maintenance doses within the range of 3-18 mg/day for most conditions
- Children's maintenance dose between 0.25-1.5 mg/kg/day
- Alternate day administration may be appropriate
- Dosage adjustments based on clinical need
- Gradual withdrawal in patients receiving more than physiological doses of systemic corticosteroids
Interaction
- Metabolized in the liver
- Recommendation to adjust dose if co-administered with liver enzyme inducers or inhibitors
Contraindications
- Hypersensitivity to the ingredients
- Patients receiving live virus immunization
Side Effects
- GI disturbances
- Musculoskeletal disturbances
- Endocrine disturbances
- Neuropsychiatric disturbances
- Ophthalmic disturbances
- Fluid and electrolyte disturbances
- Susceptibility to infection
- Impaired healing
- Hypersensitivity reactions
- Skin atrophy
- Striae
- Telangiectasia
- Acne
- Myocardial rupture following recent MI
- Thromboembolism
Pregnancy & Lactation
- Risk of intrauterine growth retardation with prolonged or repeated use during pregnancy
- Excretion in breast milk
- Potential for adrenal suppression in infants of mothers taking higher doses
Precautions & Warnings
- Caution in cardiac disease or congestive heart failure
- Caution in gastritis, oesophagitis, diverticulitis, ulcerative colitis, peptic ulcer
- Monitoring for salt and water retention, increased potassium excretion
- Caution in diabetes mellitus, osteoporosis, myasthenia gravis, renal insufficiency
- Caution in emotional instability, psychotic tendency, epilepsy
- Monitoring for corticosteroid-induced myopathy
- Special caution in liver failure, hypothyroidism, cirrhosis
- Caution in ocular herpes simplex
Use in Special Populations
- Dose monitoring in hepatic impairment
- No special precautions in renally impaired patients
- No special precautions in elderly patients
Therapeutic Class
- Glucocorticoids
Storage Conditions
- Store below 25°C
- Store in a cool, dry place
- Protect from light and moisture
- Keep out of the reach of children