Dilast 20 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Torasemide |
| Company | Incepta pharmaceuticals ltd |
Indications
- Management of edema of cardiac, renal, and hepatic origin
- Management of hypertension
- Sole therapeutic agent for hypertension
- Combination therapy for hypertension
Pharmacology
- Inhibition of Na+/K+/2CI- carrier system
- Interference with chloride binding site
- Effect on loop of Henle
- Decrease in reabsorption of sodium and chloride
- Increase in delivery of tubular fluid and electrolytes
- Increase in aldosterone production
- Promotion of sodium reabsorption at the distal tubules
- Increase in potassium excretion
- Effects on glomerular filtration rate
- Renal plasma flow
- Aldosterone levels
- Diuretic actions
- Reduction of extracellular and plasma fluid volume
- Temporary reduction in blood pressure
- Decrease in cardiac output
Dosage & Administration
- Usual initial oral dose for congestive heart failure
- Usual initial oral dose for chronic renal failure
- Usual initial oral dose for hepatic cirrhosis
- Usual initial oral dose for hypertension
- Titration of dose based on diuretic response
- Maximum single doses for different conditions
Interaction
- Increased risk of severe hypokalaemia with certain medications
- Increased risk of lithium toxicity
- Potential for ototoxicity and nephrotoxicity with specific medications
- Risk of salicylate toxicity with high dose salicylates
- Risk of toxicity with digoxin
- Reduced diuretic effect with NSAIDs
- Increased risk of hypotension with antihypertensives
Contraindications
- Hypersensitivity to torasemide and other sulfonyl ureas
- Anuria
Side Effects
- Dry mouth
- Dizziness
- Tiredness
- Skin rash
- Diarrhea
- Constipation
- Nausea
- Vomiting
- Orthostatic hypotension
- Muscle cramp
- Mild and transient nature of side effects
Pregnancy & Lactation
- Limited studies in pregnant women
- Potential excretion in human milk
- Caution during nursing
Precautions & Warnings
- Administration in diabetes
- Administration in gout
- Administration in hypotension
- Administration in liver failure
Use in Special Populations
- Safety and efficacy in children
- No established pediatric uses
Overdose Effects
- Signs and symptoms of excessive pharmacological effect
- Dehydration
- Hypovolemia
- Hypotension
- Hypokalemia
- Treatment of overdose
Therapeutic Class
- Loop diuretics
Storage Conditions
- Room temperature storage
- Protection from moisture and sunlight
- Keep out of reach of children