Lamogin 5 mg (Dispersible Tablet)
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Lamotrigine |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Adjunctive therapy for partial-onset seizures
- Adjunctive therapy for primary generalized tonic-clonic seizures
- Adjunctive therapy for Lennox-Gastaut syndrome seizures
- Monotherapy for epilepsy in patients aged 16 years and older
- Treatment for bipolar disorder in patients aged 18 years and older
Dosage & Administration
- Epilepsy Dosage:
- Escalation regimen for patients older than 12 years
- Escalation regimen for patients aged 2 to 12 years
- Initial weight-based dosing guide for patients aged 2 to 12 years taking Valproate
- Bipolar Disorder Dosage:
- Escalation regimen for adults
Description
Phenyltriazine antiepileptic used to treat epilepsy and bipolar disorder, controls seizures by inhibiting voltage-sensitive sodium channels, stabilizing neuronal membranes, and modulating release of excitatory neurotransmitters
Pharmacology
- Mechanism of Action:
- Inhibition of voltage-sensitive sodium channels
- Stabilization of neuronal membranes
- Modulation of release of excitatory neurotransmitters
- Receptor Binding:
- Weak inhibitory effect on various receptors
- Weak binding to Adenosine, adrenergic, dopamine, GABA, histamine, opioid, mACh, and serotonin receptors
Interaction
- Valproate increases Lamogin concentrations more than 2-fold
- Carbamazepine, phenytoin, phenobarbital, primidone, and rifampin decrease Lamogin concentrations by approximately 40%
- Estrogen-containing oral contraceptives decrease Lamogin concentrations by approximately 50%
- Protease inhibitors decrease Lamogin exposure
Side Effects
- Dizziness
- Headache
- Diplopia
- Nausea
- Blurred vision
- Somnolence
- Pharyngitis
- Rash
- Vomiting
- Diarrhea
- Infection
- Fever
- Abdominal pain
- Tremor
Pregnancy & Lactation
Pregnancy Category C. Excreted in human milk, potential for serious adverse reactions in nursing infants
Precautions & Warnings
- Discontinue at the first sign of rash
- Monitor for blood dyscrasias
- Monitor for suicidal behavior and ideation
- Monitor for aseptic meningitis
Use in Special Populations
- Pediatric Use:
- Lack of demonstrated safety and effectiveness in very young pediatric patients aged 1 to 24 months for epilepsy
- Lack of established safety and effectiveness in pediatric patients aged 10 to 17 years for bipolar disorder
Overdose Effects
- Ataxia
- Nystagmus
- Seizures
- Decreased level of consciousness
- Coma
- Intraventricular conduction delay
Therapeutic Class
Primary anti-epileptic drugs
Storage Conditions
- Keep out of reach of children
- Store in a dry place below 25°C temperature
- Protected from light