Lamogin 5 mg (Dispersible Tablet)

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Indications

  • Adjunctive therapy for partial-onset seizures
  • Adjunctive therapy for primary generalized tonic-clonic seizures
  • Adjunctive therapy for Lennox-Gastaut syndrome seizures
  • Monotherapy for epilepsy in patients aged 16 years and older
  • Treatment for bipolar disorder in patients aged 18 years and older

Dosage & Administration

  • Epilepsy Dosage:
    • Escalation regimen for patients older than 12 years
    • Escalation regimen for patients aged 2 to 12 years
    • Initial weight-based dosing guide for patients aged 2 to 12 years taking Valproate
  • Bipolar Disorder Dosage:
    • Escalation regimen for adults

Description

Phenyltriazine antiepileptic used to treat epilepsy and bipolar disorder, controls seizures by inhibiting voltage-sensitive sodium channels, stabilizing neuronal membranes, and modulating release of excitatory neurotransmitters

Pharmacology

  • Mechanism of Action:
    • Inhibition of voltage-sensitive sodium channels
    • Stabilization of neuronal membranes
    • Modulation of release of excitatory neurotransmitters
  • Receptor Binding:
    • Weak inhibitory effect on various receptors
    • Weak binding to Adenosine, adrenergic, dopamine, GABA, histamine, opioid, mACh, and serotonin receptors

Interaction

  • Valproate increases Lamogin concentrations more than 2-fold
  • Carbamazepine, phenytoin, phenobarbital, primidone, and rifampin decrease Lamogin concentrations by approximately 40%
  • Estrogen-containing oral contraceptives decrease Lamogin concentrations by approximately 50%
  • Protease inhibitors decrease Lamogin exposure

Side Effects

  • Dizziness
  • Headache
  • Diplopia
  • Nausea
  • Blurred vision
  • Somnolence
  • Pharyngitis
  • Rash
  • Vomiting
  • Diarrhea
  • Infection
  • Fever
  • Abdominal pain
  • Tremor

Pregnancy & Lactation

Pregnancy Category C. Excreted in human milk, potential for serious adverse reactions in nursing infants

Precautions & Warnings

  • Discontinue at the first sign of rash
  • Monitor for blood dyscrasias
  • Monitor for suicidal behavior and ideation
  • Monitor for aseptic meningitis

Use in Special Populations

  • Pediatric Use:
    • Lack of demonstrated safety and effectiveness in very young pediatric patients aged 1 to 24 months for epilepsy
    • Lack of established safety and effectiveness in pediatric patients aged 10 to 17 years for bipolar disorder

Overdose Effects

  • Ataxia
  • Nystagmus
  • Seizures
  • Decreased level of consciousness
  • Coma
  • Intraventricular conduction delay

Therapeutic Class

Primary anti-epileptic drugs

Storage Conditions

  • Keep out of reach of children
  • Store in a dry place below 25°C temperature
  • Protected from light

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