Mefoglip 2.5 mg+500 mg (Tablet)

Title

• Glipizide & Metformin

Categories

• Oral Antihyperglycemic Agents
• Diabetes Medication
• Combination Hypoglycemic Preparations

Description

• Initial therapy for type 2 diabetes
• Adjunct to diet and exercise for glycemic control
• Pharmacological mechanisms of action
• Dosage and administration instructions
• Interactions with other medications
• Contraindications and precautions
• Common side effects
• Pregnancy and lactation contraindications
• Storage conditions
• Therapeutic class

Dimensions

• Standard tablet size

Color Options

• None

Functions

• Improvement of glycemic control
• Lowering of basal and postprandial plasma glucose
• Stimulation of insulin release from the pancreas
• Decrease in hepatic glucose production
• Improvement in insulin sensitivity
• Reduction in renal clearance of Metformin

Materials

• Active ingredients: Glipizide, Metformin
• Excipients as per formulation

Technical Specifications

• Recommended starting doses
• Maximum recommended daily dose
• Storage temperature

Design Elements

• Tablet form
• Packaging design

Usability Features

• Once or twice daily administration
• Initiation at low dose with gradual escalation
• Gradual titration for advanced age patients

Indications

• Initial therapy for type 2 diabetes
• Adjunct to diet and exercise
• Improvement of glycemic control

Pharmacology

• Biguanide antihyperglycemic agent
• Improves glucose tolerance
• Lowers basal and postprandial plasma glucose
• Mechanism of action different from other oral antihyperglycemic agents
• Decreases hepatic glucose production
• Decreases intestinal absorption of glucose
• Improves insulin sensitivity
• Stimulates insulin release from the pancreas

Dosage & Administration

• Should be given once or twice daily with meals
• Recommended starting doses for initial and second-line therapy
• Maximum recommended daily dose

Interaction

• Effect of Cimetidine, Alcohol, Nifedipine on Metformin
• Potentiation of sulfonylureas by certain drugs

Contraindications

• Hypersensitivity to the drug
• Renal impairment
• Diabetic coma and ketoacidosis
• Chronic renal diseases
• Congestive heart failure
• Trauma
• Dehydration
• Alcohol dependence
• Pregnancy
• Breast-feeding

Side Effects

• Hypoglycemia
• Diarrhea
• Nausea/vomiting
• Abdominal pain
• Headache
• Musculoskeletal pain

Pregnancy & Lactation

• Contraindicated during Pregnancy & Lactation

Precautions & Warnings

• Renal excretion of Metformin
• Risk of Metformin accumulation and lactic acidosis
• Titration for advanced age patients
• Temporary suspension for surgical procedures
• Monitoring of blood glucose during concomitant therapy
• Metabolism and excretion in patients with impaired renal and/or hepatic function
• Prolonged hypoglycemia in patients with impaired function

Therapeutic Class

• Combination Oral hypoglycemic preparations

Storage Conditions

• Below 25°C
• Cool and dry place

Related Brands

• Mefoglip DS 5 mg+500 mg (Tablet) - incepta-pharmaceuticals-ltd