Simplovir 200 mg/5 ml (Oral Suspension)
70 ml bottle: ৳ 125.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Acyclovir oral |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of viral infections due to Herpes simplex virus (type I & II) and Varicella zoster virus
- Treatment of Herpes simplex virus infections of the skin and mucous membranes including initial and recurrent genital herpes and herpes labialis
- Prophylaxis of Herpes simplex infections in immunocompromised patients
Pharmacology
- Synthetic purine derivative
- Interferes with DNA synthesis
- Inhibits viral replication
- Antiviral effect on Herpes simplex virus (HSV) and Varicella-zoster virus
- Intracellular conversion to Aciclovir Triphosphate
- Absorbed from gastrointestinal tract
- Widely distributed into body tissues and fluids
- Excreted through the kidney
Dosage & Administration
- Different dosages for initial herpes simplex, immunocompromised patients, prevention of recurrence, prophylactic treatment, chicken pox, herpes zoster, and rectal herpes infections
- Dosage adjustment for renal impairment
- Treatment duration varies
Interaction
- Probenecid reduces Aciclovir excretion
- Increases plasma concentration and risk of toxicity
Contraindications
- Hypersensitivity to Aciclovir
Side Effects
- Rash
- Gastrointestinal disturbance
- Rise in bilirubin and liver-related enzymes
- Increase in blood urea and creatinine
- Decrease in hematological indices
- Headache
- Neurological reaction
- Fatigue
Pregnancy & Lactation
- Pregnancy category B
- Caution during nursing
Precautions & Warnings
- Caution in patients with renal impairment
- Dose adjustment according to creatinine clearance
- Monitor neutrophil count in neonates
Therapeutic Class
- Herpes simplex & Varicella-zoster virus infections
Storage Conditions
- Store below 25°C
- Protect from light and moisture
- Keep out of the reach of children