Trihexy 1 mg (Tablet)
Unit Price: ৳ 3.00 (3 x 10: ৳ 90.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Parkinsonism treatment
- Adjunct therapy
- Control of extrapyramidal disorders
Description
- Direct inhibitory effect on parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity for M1 subtype
- Modifies nicotinic acetylcholine receptor neurotransmission
Dosage & Administration
- Individualized dosage
- Low initial dose with gradual increase
- Before or after meals administration
- Prevention of excessive salivation
- Abrupt withdrawal avoidance
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or CNS depressants
- Intensified anticholinergic effects with monoamine oxidase inhibitors and tricyclic antidepressants
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
Pregnancy & Lactation
- Use only when clearly needed
- Excretion in human milk
- Caution in nursing women
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Precipitation of angle closure
- Administration caution in hot weather
Overdose Effects
- Central symptoms of atropine intoxication
- Recognition of peripheral signs of parasympathetic blockade
- Neuropsychiatric signs
- Symptomatic and supportive therapy
- Gastric lavage
- Respiratory support
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Temperature not exceeding 30°C
- Dry place
- Protection from light