Nitrin SR 2.6 mg (Tablet (Sustained Release))

Unit Price: ৳ 5.00 (6 x 10: ৳ 300.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Nitroglycerin tablet
Company Healthcare pharmaceuticals ltd

Indications

  • Prophylaxis of angina pectoris

Pharmacology

  • Causes relaxation of vascular smooth muscle
  • Produces vasodilator effect on both peripheral arteries and veins
  • Reduces left ventricular end-diastolic pressure
  • Reduces systemic vascular resistance
  • Reduces arterial pressure

Dosage & Administration

  • Dosage should be adjusted according to the requirement and response obtained by the individual patient
  • One Nitroglycerin 2.6 mg sustained released tablet or capsule in morning and evening for adults
  • Should be taken on an empty stomach

Interaction

  • May increase the antihypertensive properties of vasodilators, calcium antagonists, beta-adrenergic blockers
  • Concomitant use with tricyclic antidepressants and alcohol may cause high blood pressure
  • Concomitant use with phosphodiesterase type 5 (PDE5) inhibitors causes fall in blood pressure
  • Aspirin decreases the clearance and enhances the hemodynamic effects
  • Reduces the pharmacologic effects of heparin
  • Increases the bioavailability of dihydroergotamine

Contraindications

  • Known hypersensitivity to nitroglycerin, other organic nitrates, or nitrites
  • Acute myocardial infarction
  • Marked anaemia
  • Head trauma
  • Cerebral haemorrhage
  • Closed angle glaucoma

Side Effects

  • Headache
  • Tachycardia
  • Postural hypotension
  • Syncope
  • Cyanosis
  • Methaemoglobinaemia

Pregnancy & Lactation

  • No evidence relating to the safety in pregnancy and lactation

Precautions & Warnings

  • Use with caution in patients predisposed to closed-angle glaucoma
  • Abrupt discontinuation may lead to exacerbation of symptoms
  • Discontinuing long term treatment requires gradual dosage reduction
  • Particular attention required during early days of acute myocardial infarction

Overdose Effects

  • Peripheral vasodilation with a fall in blood pressure
  • Reflex tachycardia
  • Monitoring of cardiac function and general supportive measures necessary
  • Consider administration of vasopressors in life-threatening situations

Therapeutic Class

  • Coronary vasodilators

Storage Conditions

  • Cool and dry place away from light and heat
  • Keep out of the reach of children

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