Labegest 50 mg/10 ml (IV Injection or Infusion)
10 ml vial: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Labetalol hydrochloride |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Hypertension
- Hypertension in pregnancy
- Hypertension after stroke
- Hypertension with angina
- Hypertension following acute myocardial infarction
- Hypertensive crisis
- Anaesthesia when hypotensive technique is indicated
Pharmacology
- Adrenergic receptor-blocking agent
- Selective alpha 1-adrenergic and nonselective beta-adrenergic receptor-blocking actions
- Decrease in blood pressure
- Peak plasma levels occurring 1 to 2 hours after oral administration
- Plasma half-life of about 6 to 8 hours
Dosage & Administration
- Recommended initial dosage of 100 mg twice daily for adults
- Maintenance dosage between 200 and 400 mg twice daily
- Intravenous injection for reducing blood pressure quickly
- Intravenous infusion for hypertension in pregnancy, following acute myocardial infarction, after stroke, and hypotensive anaesthesia
Interaction
- Enhancement of hypotensive effects of halothane
- Careful use with Class I antiarrhythmic agents or calcium antagonists of the verapamil type
- Possible reduction in hypotensive effect when used with prostaglandin synthetase inhibitors (NSAIDs)
- Increased incidence of tremor with concomitant use of tricyclic antidepressants
- Cimetidine may increase the bioavailability of Labegest
Contraindications
- Hypersensitivity to the medicine
- Second or third degree heart block
- Infranodal A-V block
- Uncontrolled heart failure
- Sick-sinus syndrome
- Cardiogenic shock
- Severe and prolonged hypotension or severe bradycardia
- Bronchial asthma or other obstructive lung disorders
Side Effects
- Postural hypotension
- Tiredness
- Weakness
- Headache
- Rashes
- Scalp tingling
- Difficulty in micturition
- Epigastric pain
- Nausea
- Vomiting
- Liver damage
Pregnancy & Lactation
- Teratogenic studies in rats and rabbits
- No reproducible evidence of fetal malformations
- Small amounts excreted in human milk
- Caution required during nursing
Precautions & Warnings
- Rare reports of severe hepatocellular injury
- Reversible hepatic injury
- Particular care in patients with hepatic impairment
- Use with caution in patients with peripheral vascular disease
Overdose Effects
- Excessive hypotension
- Excessive bradycardia
- Gastric lavage or pharmacologically induced emesis for removal of the drug
- Administration of atropine for excessive bradycardia
- Administration of vasopressors (norepinephrine) for hypotension
Therapeutic Class
- Alpha adrenoceptor blocking drugs
- Beta-adrenoceptor blocking drugs
Storage Conditions
- Store in a cool & dry place protected from light
- Keep out of reach of children