Entroza 1 mg (Tablet)

Unit Price: ৳ 50.00 (3 x 10: ৳ 1,500.00)

Strip Price: ৳ 500.00

Medicine Details

Category	Details
Generic	Anastrozole
Company	Incepta pharmaceuticals ltd

Title

Entroza 1 mg Tablet

Description

Entroza 1 mg Tablet is used in the treatment of breast cancer. It works by lowering the amount of estrogen in the body which in turn reduces the growth of cancer cells.

Form

Tablet

Strength

1 mg

Packaging

Strip of 30 tablets

Manufacturer

Zydus Cadila

Composition

Anastrozole 1mg

Indication

Adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer, first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer, second-line treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy.

Pharmacology

Non-steroidal aromatase inhibitor that suppresses estrogen biosynthesis in peripheral tissues and in the cancer tissue itself by specifically inhibiting the aromatase enzyme.

Dosage

One tablet 1 mg once a day for advanced breast cancer; duration for adjuvant treatment in early breast cancer is unknown.

HepaticImpairment

No dosage changes for mild-to-moderate impairment; not studied in severe impairment.

RenalImpairment

No dosage changes necessary.

PediatricUse

Safety and efficacy not established.

GeriatricUse

Pharmacokinetics not affected by age.

Interaction

Reduces plasma concentration if co-administered with tamoxifen; should not be used with estrogen-containing therapies; unlikely to affect other drugs via cytochrome P450 inhibition.

Contraindications

Pregnancy and premenopausal women
Hypersensitivity to the drug or its excipients

SideEffects

Serious adverse reactions: skin reactions, allergic reactions, liver function changes
Common adverse reactions: hot flashes, asthenia, arthritis, pain, hypertension, depression, nausea, vomiting, rash, osteoporosis, fractures, back pain, insomnia, headache, bone pain, peripheral edema, increased cough, dyspnea, pharyngitis, lymphedema.

PregnancyLactation

Pregnancy Category X; unknown excretion in human milk, decision should consider importance of drug to the mother.

PrecautionsWarnings

Increased incidence of ischemic cardiovascular events in women with pre-existing ischemic heart disease
Mean decrease in bone mineral density compared to baseline
More patients reported elevated serum cholesterol

OverdoseEffects

Well tolerated up to 60 mg in healthy male volunteers and up to 10 mg daily in postmenopausal women with advanced breast cancer; no specific antidote, treatment must be symptomatic.