Isentin M 2.5 mg+1000 mg (Tablet)
Unit Price: ৳ 16.00 (5 x 6: ৳ 480.00)
Strip Price: ৳ 96.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Therapeutic Class
- Combination Oral hypoglycemic preparations
Indications
- Improving glycemic control in adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
Pharmacology
- Inhibitor of DPP-4 (dipeptidyl peptidase-4)
- Inhibits degradation of incretin hormones GLP-1 and GIP
- Stimulates insulin release from pancreatic beta cells
- Decreases glucagon secretion from pancreatic alpha cells
- Lowers basal and postprandial plasma glucose levels
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
- Individualized dosage based on effectiveness and tolerability
- Gradual dose escalation to reduce gastrointestinal side effects
- Different dosages for immediate release and extended release tablets
- Recommended starting doses for different patient scenarios
Interaction
- Potential interaction with cationic drugs via renal tubular transport systems
- Interaction with carbonic anhydrase inhibitors
- Interaction with inducers of P-glycoprotein and CYP3A4 enzymes
- Impact on drugs affecting glycemic control
Contraindications
- Contraindicated in patients with renal impairment
- Contraindicated in acute or chronic metabolic acidosis
- Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Most common side effects are nasopharyngitis and diarrhea
- Higher risk of hypoglycemia when used with sulfonylureas
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Caution advised during pregnancy and lactation
Precautions & Warnings
- Discontinue in case of lactic acidosis or suspected pancreatitis
- Discontinue temporarily for specific medical procedures
- Monitor Vitamin B12 levels due to potential lowering by Metformin
- Symptoms and precautions for lactic acidosis
- Instructions for alcohol consumption, other medicines, counseling, travel, and emergencies
- Caution for hypoglycemia and its management
Overdose Effects
- Supportive measures in case of overdose
- Dialyzable nature of Metformin Hydrochloride
- No dose-related clinical adverse reactions up to 600 mg of Linagliptin
- Hypoglycemia and lactic acidosis reported in Metformin Hydrochloride overdose cases
Storage Conditions
- Keep in a cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of the reach of children