Lovanzo 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Omeprazole
Company Everest pharmaceuticals ltd
Also available as
Lovanzo 20 mg capsule

Indications

  • Gastric and duodenal ulcer
  • NSAID-associated duodenal and gastric ulcer
  • Prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
  • Gastro-esophageal reflux disease
  • Long-term management of acid reflux disease
  • Acid-related dyspepsia
  • Severe ulcerating reflux esophagitis
  • Prophylaxis of acid aspiration during general anesthesia
  • Zollinger-Ellison syndrome
  • Helicobacter pylori-induced peptic ulcer

Pharmacology

  • Inhibitor of gastric acid secretion
  • Blocks hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system
  • Onset of the antisecretory effect occurs within one hour
  • Maximum effect within two hours
  • Inhibition of secretion lasts up to 72 hours
  • Secretory activity returns gradually over 3 to 5 days after discontinuation

Dosage

  • Varied dosage for different conditions
  • Includes oral and IV administration

Administration

  • Directions for IV Injection
  • Directions for IV Infusion
  • Instructions for reconstitution and administration

Interaction

  • Effects on the absorption of ketoconazole
  • Metabolism through cytochrome P450 affecting diazepam, phenytoin, and warfarin
  • Monitoring and potential dose adjustments for warfarin and phenytoin
  • Plasma concentrations of Lovanzo and clarithromycin during concomitant administration
  • Influence on the bioavailability of digoxin
  • No interaction with phenacetin, theophylline, caffeine, propranolol, metoprolol, cyclosporin, lidocaine, quinidine, estradiol, amoxycillin, antacids, piroxicam, diclofenac, naproxen

Contraindications

  • Known hypersensitivity to omeprazole
  • Contraindicated if gastric ulcer is suspected and malignancy needs to be excluded

Side Effects

  • Mild and reversible adverse reactions
  • Reported skin reactions like rash, urticaria, and pruritus
  • Digestive system reactions such as diarrhoea, headache, constipation, and nausea
  • Neurological reactions like dizziness, headache, somnolence, and insomnia
  • Respiratory reactions like bronchospasm
  • Hematological reactions like leucopenia, thrombocytopenia, and pancytopenia
  • Hepatic reactions like increases in liver enzymes
  • Other reactions like photosensitivity, alopecia, dry mouth, and peripheral oedema

Pregnancy & Lactation

  • No adverse effects of omeprazole on pregnancy or fetus/newborn child
  • Use during pregnancy is possible
  • No information on passage into breast milk or effects on the neonate

Precautions & Warnings

  • Avoid concomitant use of clopidogrel and Lovanzo
  • Possible risk of osteoporosis-related fractures with PPI therapy
  • Atrophic gastritis noted in patients treated long-term with Lovanzo
  • Potential methotrexate toxicities with PPIs

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep in a dry place away from light and heat

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