Milium 10 mg (Tablet)
Unit Price: ৳ 2.50 (5 x 10: ৳ 125.00)
Strip Price: ৳ 25.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Everest pharmaceuticals ltd |
Title and Description
- Milium 10 mg Tablet
- Dopamine antagonist medication
- Used to treat nausea and vomiting
- Relieves dyspeptic symptoms, acute nausea and vomiting, and symptoms of Parkinson's disease
Categories
- Gastrointestinal medication
- Antiemetic medication
- Prokinetic medication
- Motility stimulants/Dopamine antagonist
- Pharmacological medication
Dosage and Administration
- Should be taken 15-30 minutes before meals
- Recommended oral dose for adults and children
- Can be taken by rectum in suppositories
- Maximum period of treatment is 12 weeks
Mode of Action
- Dopamine antagonist that blocks dopamine receptors
- Gastroprokinetic action based on blocking effect of dopamine receptors in gastrointestinal tract
- Restores normal motility and tone of upper gastrointestinal tract
- Facilitates gastric emptying and enhances peristalsis
Interaction
- Concomitant administration of anticholinergic drugs may antagonize the antidyspeptic effect
- Antacids and antisecretory drugs should not be given simultaneously
- Metabolic pathway through CYP3A4
- Potential interactions with CYP3A4 inhibitors
- May influence absorption of concomitantly orally administered drugs
Indications
- Relieves dyspeptic symptom complex including epigastric fullness, abdominal pain, nausea, and heartburn
- Used for acute nausea and vomiting of various origins
- Indicated in Parkinson's disease-related nausea and vomiting
- Speeds barium transit in radiological studies
Contraindications
- Hypersensitivity to the drug
- Neonates
- Gastrointestinal hemorrhage, obstruction, or perforation
- Prolactin releasing pituitary tumor (prolactinoma)
Side Effects
- Rare side-effects include transient intestinal cramps
- Rare extrapyramidal phenomena in young children and adults
- Possible increase in plasma prolactin level
- Rare allergic reactions such as rash and urticaria
Pregnancy & Lactation
- Use during first trimester only if justified by therapeutic benefit
- No evidence of increase in risk of malformations in humans
- Excretion in breast milk with lower concentrations than in plasma
- Nursing not recommended unless benefits outweigh potential risk
Precautions & Warnings
- Caution in children due to risk of extrapyramidal reactions
- Caution in patients with hepatic impairment
- Use with caution in infants and under close medical supervision
- Dosage adjustment in severe renal insufficiency
Use in Special Populations
- Use with caution in infants due to immature blood-brain barrier
- Caution in patients with hepatic impairment
- Dosing frequency reduction in severe renal insufficiency
- Regular review for patients on prolonged therapy
Overdose Effects
- Symptoms may include drowsiness, disorientation, and extrapyramidal reactions
- Recommendation for activated charcoal administration and close observation
- Use of anticholinergic and antiparkinson drugs in controlling extrapyramidal reactions
Therapeutic Class
- Motility Stimulants
- Motility stimulants/Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C, protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
- Chemical Structure Image Available
Common Questions
- Used to treat nausea, vomiting, and indigestion
- Relieves dyspeptic symptoms
- Caution for dizziness and sleepiness
- Avoid alcohol consumption
- Management of dry mouth and symptoms persistence notice to doctor for consultation