Colostat 20 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Atorvastatin calcium
Company Ibn sina pharmaceuticals ltd
Also available as
Colostat 10 mg tablet

Product title

Colostat 20 mg Tablet

Therapeutic class

Other Anti-anginal & Anti-ischaemic drugs, Statins

Indications

  • Reduce total cholesterol and LDL cholesterol in patients with heterozygous and homozygous familial hypercholesterolaemia
  • Reduce elevated cholesterol and triglycerides in patients with mixed dyslipidemia (Fredrickson Type Ia and Ib)
  • Treatment of patients with elevated serum triglyceride levels in hypertriglyceridaemia (Fredrickson Type IV)
  • Treatment of patients with dysbetalipoproteinaemia (Fredrickson Type III)
  • Reduce cardiac ischaemic events in patients with asymptomatic or mild to moderate symptomatic coronary artery disease with elevated LDL-cholesterol level
  • Reduce total and LDL-cholesterol concentrations in patients with hypercholesterolemia associated with or exacerbated by diabetes mellitus or renal transplantation

Pharmacology

  • Mode of action: Selective inhibitor of HMG-CoA reductase
  • Absorption: Rapidly absorbed after oral administration; maximum plasma concentrations occur within 1 to 2 hours
  • Distribution: Mean volume of distribution is approximately 381 liters; 98% bound to plasma proteins
  • Metabolism: Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products
  • Excretion: Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism

Dosage and administration

  • Adults:
    • Primary hypercholesterolaemia and combined hyperlipidaemia: Usually 10 mg once daily; may be increased at intervals of at least 4 weeks to max. 80 mg once daily
    • Familial hypercholesterolaemia: Initially 10 mg daily, increased at intervals of at least 4 weeks to 40 mg once daily; if necessary, further increased to max. 80 mg once daily
    • Prevention of cardiovascular events: Initially 10 mg once daily adjusted according to response
  • Children:
    • Primary hypercholesterolaemia and combined hyperlipidaemia: Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to max. 20 mg once daily
    • Familial hypercholesterolaemia: Initially 10 mg once daily, increased if necessary at intervals of at least 4 weeks to usual max. 80 mg once daily

Interactions

  • Cyclosporine
  • Fibric acid derivatives
  • Niacin (nicotinic acid)
  • Erythromycin
  • Azole antifungals
  • Antacid
  • Colestipol
  • Digoxin
  • Oral Contraceptives
  • Warfarin

Contraindications

  • Hypersensitivity to any component of this medication
  • Active liver disease or unexplained persistent elevations of serum transaminases
  • History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side effects

  • Constipation
  • Flatulence
  • Dyspepsia
  • Abdominal pain
  • Infection
  • Headache
  • Back pain
  • Rash
  • Asthenia
  • Arthralgia
  • Myalgia

Pregnancy and lactation

  • Pregnancy: Contraindicated; safety in pregnant women not established; rare reports of congenital anomalies; animal studies show toxicity to reproduction
  • Lactation: Not known whether excreted in human milk; contraindicated during breastfeeding

Precautions and warnings

  • Liver function tests should be performed before the initiation of treatment and periodically thereafter
  • Use with caution in patients who consume substantial quantities of alcohol or have a history of liver disease
  • Discontinue therapy if markedly elevated CPK levels occur or myopathy is diagnosed or suspected

Use in special populations

  • Geriatric: Plasma concentrations are higher in healthy elderly subjects than in young adults
  • Pediatric: Pharmacokinetic data not available
  • Gender: No clinically significant difference in LDL-C reduction between men and women
  • Renal insufficiency: No influence on the plasma concentrations or LDL-C reduction
  • Hemodialysis: Not expected to significantly enhance clearance
  • Hepatic insufficiency: Plasma concentrations are markedly increased in patients with chronic alcoholic liver disease

Overdose effects

Specific treatment not available; treat symptomatically; monitor liver function tests and serum CK levels

Storage conditions

Keep in a dry place away from light and heat; keep out of the reach of children

Chemical structure

  • Molecular formula: C33H35FN2O5
  • Chemical structure image url: https://medex.com.bd/storage/res/g-res-92-atorvastatin-calcium-chemical-structure-vKDE8RIA4syu8MLTgdLW.svg

Commonly asked questions

  • What is Colostat 20 mg Tablet?
  • How should I take Colostat 20 mg Tablet?
  • What are the uses of Colostat 20 mg Tablet?
  • What are the Side Effects of Colostat 20 mg Tablet?
  • What are the instructions for storage and disposal Colostat 20 mg Tablet?
  • Is Colostat 20 mg Tablet used for lowering cholesterol?
  • Will taking Colostat 20 mg Tablet increase my risk of diabetes?
  • For how long do I need to take Colostat 20 mg Tablet? Is it safe for long-term use?
  • Does Colostat 20 mg Tablet cause weight loss?
  • Can I stop taking Colostat 20 mg Tablet?
  • Does Colostat 20 mg Tablet cause memory loss?
  • Does Colostat 20 mg Tablet make you tired?
  • Can Colostat 20 mg Tablet be prescribed to children?
  • Is Colostat 20 mg Tablet a blood thinner?
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