Nitrocontin 6.4 mg (Tablet (Controlled Release))

Unit Price: ৳ 9.00 (1 x 30: ৳ 270.00)
Strip Price: ৳ 270.00

Medicine Details

Category Details
Generic Nitroglycerin tablet
Company Mundipharma bd pvt ltd
Also available as
Nitrocontin 26 mg tablet

Indications

  • Prophylaxis of angina pectoris

Pharmacology

  • Causes relaxation of vascular smooth muscle
  • Produces vasodilator effect on both peripheral arteries and veins

Dosage & Administration

  • Dosage adjustment according to individual patient's requirement and response
  • One 2.6 mg sustained released tablet or capsule in morning and evening for adults
  • To be taken on an empty stomach

Interaction

  • May increase antihypertensive properties of vasodilators, calcium antagonists, beta-adrenergic blockers
  • Concomitant use with tricyclic antidepressants and alcohol may cause high blood pressure
  • Concomitant use with phosphodiesterase type 5 (PDE5) inhibitors causes fall in blood pressure
  • Aspirin decreases clearance and enhances hemodynamic effects
  • Reduces the pharmacologic effects of heparin
  • Increases the bioavailability of dihydroergotamine

Contraindications

  • Known hypersensitivity to nitroglycerin, other organic nitrates, or nitrites or to the excipients of the medicine
  • Acute myocardial infarction
  • Marked anaemia
  • Head trauma
  • Cerebral haemorrhage
  • Closed angle glaucoma

Side Effects

  • Headache at the onset of treatment
  • Tachycardia
  • Postural hypotension and syncope
  • Cyanosis
  • Methaemoglobinaemia

Pregnancy & Lactation

  • No evidence of safety in pregnancy and lactation
  • Should be administered to pregnant women and nursing mothers only if essential

Precautions & Warnings

  • Use with caution in patients predisposed to closed-angle glaucoma
  • Abrupt discontinuation may lead to exacerbation of symptoms
  • Discontinuing long term treatment should be done gradually over several days
  • Particular attention during the early days of acute myocardial infarction

Overdose Effects

  • Peripheral vasodilation with a fall in blood pressure
  • Reflex tachycardia
  • Monitoring of cardiac function and general supportive measures to be used
  • Circulating plasma volume should be increased by fluid substitution
  • Vasopressors administration to be considered in life-threatening situations

Therapeutic Class

  • Nitrates: Coronary vasodilators

Storage Conditions

  • Store in a cool and dry place away from light and heat
  • Keep all medicines out of the reach of children

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