Vardamate 10 mg (Tablet)

Title

• Vardamate

Category

• Medicine
• Pharmaceutical

Indications

• Treats erectile dysfunction (ED)

Mode of Action

• Selective inhibitor of cyclic guanosine monophosphate (cGMP) specific phosphodiesterase type 5 (PDE5)

Pharmacology

• Initiates penile erection by relaxing smooth muscle and increasing blood flow into the penis

Dosage & Administration

• Recommended starting dose: 10 mg once daily, taken orally approximately 60 minutes before sexual activity
• Dose can be increased to a maximum of 20 mg or decreased to 5 mg based on efficacy and side effects
• Maximum recommended dosing frequency is once per day
• Can be taken with or without food
• Geriatrics: Consider a starting dose of 5 mg for patients >65 years of age
• Renal impaired patients: No dose adjustment required
• Hepatic impaired patients: A starting dose of 5 mg is recommended for moderate hepatic impairment, and the maximum dose should not exceed 10 mg. Not recommended for patients with severe hepatic impairment

Interactions

• Can potentiate the blood pressure lowering effect of antihypertensive agents
• Caution should be taken when co-administered with other vasodilators including alpha blockers
• Does not potentiate the hypotensive effect of alcohol
• CYP3A4 inhibitors may reduce Vardamate excretion from the body

Contraindications

• Do not administer with nitrates or nitric oxide donors
• Hypersensitivity to Vardenafil or any of the product's ingredients

Side Effects

• Headache
• Flushing
• Stuffy or runny nose
• Indigestion
• Upset stomach
• Dizziness
• Back pain

Pregnancy & Lactation

• Not indicated for women

Precautions & Warnings

• Physicians should consider the cardiovascular status of their patients
• Degree of cardiac risk associated with sexual activity
• Not recommended for men for whom sexual activity is not recommended due to underlying cardiovascular status

Overdose Effects

• Single 120 mg dose resulted in blurred vision and back pain
• No serious adverse effects observed with single doses up to 80 mg or multiple doses up to 40 mg administered once daily over 4 weeks
• In cases of overdose, contact a doctor immediately

Therapeutic Class

• Drugs for Erectile Dysfunction

Storage Conditions

• Store at room temperature
• Protect from light and moisture
• Keep out of the reach of children

Related Brands

• Vardamate 20 mg (Tablet) - square-pharmaceuticals-plc