Lopoten Plus 100 mg+25 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Losartan potassium hydrochlorothiazide
Company Euro pharma ltd
Also available as
Lopoten plus 50 mg tablet

Title

  • Lopoten Plus

Categories

  • Medicine
  • Healthcare
  • Pharmaceutical

Description

  • Treatment of hypertension
  • Reduction of stroke risk in patients with hypertension and left ventricular hypertrophy
  • Pharmacology involving angiotensin II, ACE inhibition, aldosterone secretion, thiazide diuretic action
  • Dosage instructions for different types of hypertension
  • Administration with or without food
  • Drug interactions with other antihypertensive agents, diuretics, and antidiabetic drugs
  • Contraindications for hypersensitive patients and those with anuria or sulfonamide hypersensitivity
  • Mild side effects including dizziness, hyperkalaemia, angioedema, vertigo, gastrointestinal disturbances
  • Pregnancy and lactation precautions
  • Hypersensitivity, electrolyte imbalance, hypokalemia, impaired renal function, symptomatic hypotension precautions
  • Use in patients with renal impairment, hepatic impairment, and pediatric patients
  • Effects of overdosage
  • Therapeutic class as combined antihypertensive preparations
  • Storage conditions below 30°C

Color Options

  • None

Dimensions

  • None

Functions

  • Treatment of hypertension
  • Reduction of stroke risk

Materials

  • Losartan
  • Hydrochlorothiazide

Technical Specifications

  • Usual starting dose of 50/12.5 tablet once daily
  • Dosage increment to 100/25 tablet once daily
  • Three-week attainment of antihypertensive effect
  • No initial dosage adjustment for elderly patients
  • Usual starting dose for severe hypertension of 50/12.5 tablet once daily
  • Maximum dose for severe hypertension of 100/25 tablet once daily
  • Increased plasma renin activity and aldosterone secretion
  • Renal tubular electrolyte reabsorption effects

Design Elements

  • Generic name containing 'Losartan' and 'Hydrochlorothiazide'
  • Clear dosage instructions
  • Moderate number of side effects

Usability Features

  • Administration with other antihypertensive agents
  • Administration with or without food

Other Features

  • Storage conditions to keep out of reach of children

Maximum Dose

  • 100/25 once daily

Hypersensitivity Precautions

  • Avoidance in hypersensitive patients
  • Avoidance in patients with anuria or sulfonamide hypersensitivity

Renal Impairment Uses

  • Usual regimens of therapy with 50/12.5 in patients with creatinine clearance >30 ml/min
  • Preferred use of loop diuretics in case of severe renal impairment

Hepatic Impairment Uses

  • Not recommended for titration in patients with hepatic impairment

Pediatric Uses

  • Safety and effectiveness in pediatric patients not established

Side Effects Info

  • Occasional symptomatic hypotension including dizziness
  • Occasional hyperkalaemia
  • Occasional angioedema
  • Rarely reported gastrointestinal disturbances, vertigo, oedema, dyspnoea, headache, sleep disorders, malaise, urticaria, pruritus, rash
  • Rarely reported hepatitis, atrial fibrillation, cerebrovascular accident, syncope, paraesthesia
  • Occasional occurrence of pancreatitis, anaphylaxis, cough, depression, erectile dysfunction, anaemia, thrombocytopenia, hyponatraemia, arthralgia, myalgia, renal impairment, rhabdomyolysis, tinnitus, photosensitivity, vasculitis

Drug Interactions

  • No significant drug-drug interactions with Losartan and Hydrochlorothiazide
  • Potential interaction with potassium-sparing diuretics, potassium supplements, salt substitutes, non-steroidal anti-inflammatory drug Indomethacin
  • Potential interactions with alcohol, barbiturates, narcotics, antidiabetic drugs, other antihypertensive drugs, cholestyramine and colestipol resins

Administration Compatibility

  • May be administered with other antihypertensive agents
  • May be administered with or without food

Special Population Uses

  • Use in patients with renal impairment
  • Use in patients with more severe renal impairment preferring loop diuretics over thiazides
  • Not recommended in patients with hepatic impairment
  • Safety and effectiveness not established in pediatric patients

Overdose Effects Info

  • Manifestations of hypotension, tachycardia, bradycardia
  • Supportive treatment for symptomatic hypotension
  • Inability for removal by hemodialysis

Pregnancy & Lactation Warnings

  • Avoidance in pregnancy unless essential
  • Adverse effects on fetal and neonatal blood pressure control and renal function
  • Reports of skull defects, oligohydramnios
  • Not recommended in breastfeeding

Contraindicated Patients

  • Hypersensitive patients
  • Patients with anuria or sulfonamide hypersensitivity

Therapeutic Class

  • Combined antihypertensive preparations

Safety Storage Conditions

  • Store below 30°C
  • Keep out of the reach of children

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