Amlevo 2.5 mg (Tablet)
Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Levamlodipine maleate |
| Company | Eskayef pharmaceuticals ltd |
| Also available as | Amlevo 5 mg tablet |
Indications
- Treatment of hypertension
- Lowering blood pressure
- Reducing risk of cardiovascular events
Pharmacology
- Dihydropyridine calcium antagonist
- Inhibits calcium ion influx
- Pharmacologically active isomer
Absorption
- Tmax of 6-12 hours
- Bioavailability of 64-90%
- Not significantly affected by food
Distribution
- Volume of distribution similar to amlodipine
- Volume of distribution of amlodipine is 21 L/kg
Metabolism and Excretion
- 90% metabolized to inactive metabolites
- Mainly metabolized by CYP3A4
- 60% eliminated in urine
Dosage & Administration
- Oral route of administration
- Usual initial dose is 2.5 mg once daily
- Maximum dose is 5 mg once daily
- Dosage adjustment for elderly and hepatically impaired patients
- Pediatric dosage
Interaction
- Effect of CYP3A inhibitors and inducers
- Interaction with simvastatin and immunosuppressants
- Absorption unaffected by food
- Avoidance of grapefruit products and natural licorice
Contraindications
- Known sensitivity to amlodipine
Side Effects
- Common and rare side effects
Pregnancy & Lactation
- Limited data on pregnancy use
- No adverse effects on the breastfed infant
Precautions & Warnings
- Possible hypotension
- Increased angina or myocardial infarction
- Caution in patients with hepatic failure
Overdose Effects
- Excessive peripheral vasodilation with hypotension
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Store in cool and dry place
- Protect from light and moisture
- Keep out of reach of children