Nitro SR 2.6 mg (Tablet (Sustained Release))

Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Nitroglycerin tablet
Company Unimed unihealth pharmaceuticals ltd

Indications

  • Prophylaxis of angina pectoris

Pharmacology

  • Causes relaxation of vascular smooth muscle
  • Produces a vasodilator effect on peripheral arteries and veins
  • Reduces left ventricular end-diastolic pressure (preload)
  • Reduces systemic vascular resistance and arterial pressure (afterload)

Dosage & Administration

  • Dosage should be adjusted according to individual patient and severity of anginal pain
  • For adults, one Nitroglycerin 2.6 mg sustained release tablet or capsule in morning and evening
  • To be taken empty stomach

Interaction

  • May increase antihypertensive properties of vasodilators, calcium antagonists, and beta-adrenergic blockers
  • Concomitant use with tricyclic antidepressants and alcohol may cause high blood pressure
  • Concomitant use with phosphodiesterase type 5 (PDE5) inhibitors cause fall in blood pressure
  • Aspirin decreases clearance and enhances hemodynamic effects
  • May reduce pharmacologic effects of heparin
  • Increases bioavailability of dihydroergotamine

Contraindications

  • Known hypersensitivity to nitroglycerin, other organic nitrates, or nitrites
  • Acute myocardial infarction
  • Marked anemia
  • Head trauma
  • Cerebral hemorrhage
  • Closed angle glaucoma

Side Effects

  • Headache
  • Tachycardia
  • Postural hypotension and syncope
  • Cyanosis
  • Methaemoglobinaemia

Pregnancy & Lactation

  • No evidence relating to safety in pregnancy and lactation
  • Should be administered to pregnant women and nursing mothers only if considered essential by the physician

Precautions & Warnings

  • Use with caution in patients predisposed to closed-angle glaucoma
  • Abrupt discontinuation may lead to exacerbation of symptoms
  • Discontinuing long term treatment requires gradual reduction in dosage over several days and careful monitoring
  • Requires particular attention to hemodynamic monitoring and clinical status during early days of acute myocardial infarction

Overdose Effects

  • Peripheral vasodilation
  • Fall in blood pressure
  • Reflex tachycardia
  • Monitoring of cardiac function and general supportive measures should be used
  • Administer vasopressors in life-threatening situations

Therapeutic Class

  • Nitrates: Coronary vasodilators

Storage Conditions

  • Store in a cool and dry place away from light and heat
  • Keep all medicines out of the reach of children

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