Apridex 40 mg (Capsule)
Unit Price: ৳ 50.00 (1 x 5: ৳ 250.00)
Strip Price: ৳ 250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Aprepitant |
| Company | Drug international ltd |
Title and Categories
- Apridex
- Anti-emetic drugs
Indications
- Prevention of postoperative nausea and vomiting (PONV)
- Prevention of Chemotherapy Induced Nausea and Vomiting (CINV)
Pharmacology
- Selective high affinity antagonist of human substance P neurokinin 1 (NK1) receptors
Dosage
- Oral dosage of Aprepitant is 40 mg within 3 hours prior to induction of anesthesia
- Specific regimen for highly emetogenic cancer chemotherapy
- Specific regimen for moderately emetogenic cancer chemotherapy
Administration
- May be taken with or without food
- No dosage adjustment necessary for elderly patients
Interaction
- Substrate, weak-to-moderate (dose dependent) inhibitor, and an inducer of CYP3A4
- Inducer of CYP2C9
- Precautions with coadministration with drugs that use CYP3A4 or CYP2C9
- Effect on hormonal contraceptives
Contraindications
- Hypersensitivity to any component of the product
- Concurrent use with Pimozide, Terfenadine, Astemizole & Cisapride
Side Effects
- Constipation
- Hypotension
- Pruritus
- Pyrexia
Pregnancy & Lactation
- Pregnancy Category B
- Use during pregnancy only if clearly needed
- Unknown excretion in human milk
- Decision on nursing based on patient's importance
Use in Special Populations
- No dosage adjustment for patients with Renal Impairment or end-stage renal disease (ESRD) undergoing hemodialysis
- No dosage adjustment for patients with mild to moderate hepatic impairment
Overdose Effects
- No specific information available on treatment of overdosage
- Drowsiness and headache seen due to overdose
- Discontinuation of Apridex
- General supportive treatment and monitoring provided
- Ineffectiveness of medicine-induced emesis
- Inability to be removed by hemodialysis
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children