Singlin 0.5 mg (Tablet)

Indications

• Lower blood glucose in type 2 diabetes mellitus patients
• Adjunct to diet and exercise
• Combination use with Metformin

Description

• Oral blood-glucose-lowering drug
• Management of Type 2 diabetes mellitus (NIDDM)
• Rapid onset of action and rapid elimination

Pharmacology

• Binds to specific receptors in the cell membrane
• Closure of ATP dependent K+ channels
• Depolarization of cell membrane
• Ca++ influx and increased intracellular Ca++
• Stimulation of insulin secretion

Dosage & Administration

• Starting dose for patients not previously treated or HbA1c <8%: 0.5 mg
• Initial dose for previously treated patients with HbA1c >8%: 1 or 2 mg
• Should be taken immediately or up to 30 minutes before each meal
• Dosage adjustment according to response
• Maximum dose: 16 mg daily

Interaction

• Possible interactions with other medications
• Inhibitors of cytochrome P450 enzyme system
• Inducers of cytochrome P450 enzyme system
• No significant effect on Digoxin, Theophyllin, or Warfarin
• Risk of hypoglycemia with certain drugs

Contraindications

• Diabetic ketoacidosis
• Type 1 diabetes mellitus
• Known hypersensitivity to the drug or its inactive ingredients

Side Effects

• Hypoglycemia and related symptoms
• Upper respiratory tract infections
• Diarrhea, constipation, nausea, vomiting
• Hypersensitivity reactions: rashes, urticaria

Pregnancy & Lactation

• Safety not established in pregnant women
• Use during pregnancy only if clearly needed
• Unknown excretion in human milk
• Consideration for discontinuation during nursing

Precautions & Warnings

• Substitution of insulin during concurrent illness and surgery
• Capable of producing hypoglycemia
• Administration with meals to lessen risk of hypoglycemia

Overdose Effects

• Few adverse effects up to 80 mg
• Severe hypoglycemic reactions infrequently occur

Therapeutic Class

• Meglitinide Analogues

Storage Conditions

• Do not store above 30°C
• Keep away from light
• Keep out of the reach of children

Related Brands

• Singlin 2 mg (Tablet) - renata-limited
• Singlin 1 mg (Tablet) - renata-limited