Domperidon 10 mg (Tablet)
Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Biogen pharmaceuticals ltd |
Title and Categories
- Domperidone 10 mg Tablet
- Medicine
- Health & Wellness
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Parkinson's disease
- Radiological studies
- Non-ulcer dyspepsia
Pharmacology
- Dopamine antagonist
- Blocks dopamine receptors
- Gastroprokinetic action
- Influence on gastrointestinal motility
- Restores normal motility and tone
- Facilitates gastric emptying
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
Dosage & Administration
- Should be taken 15-30 minutes before meals
- Maximum dose for adults is 80 mg daily
- Different doses for dyspeptic symptom and acute conditions
- Rectal administration for some patients
- Different dosage for children based on body weight
Interaction
- Antagonism with anticholinergic drugs
- Lower oral bioavailability with antacids and antisecretory drugs
- Metabolic pathway through CYP3A4
- Inhibition by azole antifungals and macrolide antibiotics
- Potential impact on orally administered drugs
Contraindications
- Known hypersensitivity to the drug
- Neonates
- Dangerous gastrointestinal stimulation
Side Effects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Increase in plasma prolactin level
- Rare allergic reactions
- Possible neurological side-effects in infants
Pregnancy & Lactation
- Use only if justified by anticipated benefit
- No evidence of increased risk of malformations in humans
- Excreted in breast milk of lactating rats
- Not recommended for nursing mothers
Precautions & Warnings
- Increased risk of extra-pyramidal reactions in children
- Caution in patients with hepatic impairment
Use in Special Populations
- Caution in infants due to immature blood-brain barrier
- Caution in patients with liver and kidney disorders
- Dosing frequency adjustment for patients with renal insufficiency
Overdose Effects
- Drowsiness
- Disorientation
- Extrapyramidal reactions
- Recommendation for management with activated charcoal
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
Common Questions
- Used to treat nausea and vomiting
- Helps relieve indigestion
- Caution with alcohol consumption
- Possible side effects: dizziness, dry mouth, watery diarrhea