Biomonas 10 mg (Tablet)

Unit Price: ৳ 14.00 (3 x 10: ৳ 420.00)
Strip Price: ৳ 140.00

Medicine Details

Category Details
Generic Montelukast sodium
Company Biogen pharmaceuticals ltd

Indications

  • Prophylaxis and chronic treatment of asthma
  • Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
  • Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1). The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. Cysteinyl leukotrienes and leukotriene receptor occupation have been correlated with the pathophysiology of asthma & allergic rhinitis, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma.

Dosage & Administration

  • Adults and adolescents with asthma or seasonal allergic rhinitis: Montelukast 10 mg tablet once daily.
  • Pediatric patients with asthma or seasonal allergic rhinitis: Montelukast 5 mg tablet once daily, Montelukast 4 mg tablet once daily, Montelukast 4 mg oral granules once daily.

Interaction

Biomonas has been administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma with no apparent increase in adverse reactions. In drug interaction studies, the recommended clinical dose of Biomonas did not have clinically important effects on the pharmacokinetics of theophylline, prednisone, prednisolone, oral contraceptives, terfenadine, digoxin, warfarin, thyroid hormones, sedative hypnotics, non-steroidal anti-inflammatory agents, benzodiazepines, decongestants, phenobarbital, or rifampin.

Contraindications

Montelukast is contraindicated in patients who are hypersensitive to any component of this product.

Side Effects

  • Common:
    • Diarrhoea
    • Fever
    • Gastrointestinal discomfort
    • Headache
    • Nausea
    • Vomiting
    • Skin reactions
    • Upper respiratory tract infection
  • Uncommon:
    • Akathisia
    • Anxiety
    • Arthralgia
    • Asthenia
    • Abnormal behavior
    • Depression
    • Dizziness
    • Drowsiness
    • Dry mouth
    • Haemorrhage
    • Irritability
    • Malaise
    • Muscle complaints
    • Oedema
    • Seizure
    • Abnormal sensation
    • Sleep disorders
  • Rare:
    • Angioedema
    • Concentration impaired
    • Disorientation
    • Eosinophilic granulomatosis with polyangiitis
    • Erythema nodosum
    • Hallucination
    • Hepatic disorders
    • Memory loss
    • Palpitations
    • Pulmonary eosinophilia
    • Suicidal tendencies
    • Tremor

Pregnancy & Lactation

Montelukast crosses the placenta following oral dosing in rats and rabbits. Caution should be exercised when Montelukast is given to a nursing mother.

Precautions & Warnings

Biomonas is not indicated for use in the reversal of bronchospasm in acute asthma attacks, including status asthmaticus. Patients should be advised to have appropriate rescue medication available. Therapy can be continued during acute exacerbations of asthma. Biomonas should not be abruptly substituted for inhaled or oral corticosteroids. Biomonas should not be used as monotherapy for the treatment and management of exercise induced bronchospasm.

Overdose Effects

In the event of overdose, it is reasonable to employ the usual supportive measures; e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive therapy, if required.

Therapeutic Class

Leukotriene receptor antagonists

Storage Conditions

Store in cool & dry place below 30°C, protect from light & moisture. Keep out of reach of children.

Chemical Structure

  • Molecular Formula: C35H36ClNO3S
  • Chemical Structure Image URL: https://medex.com.bd/storage/res/g-res-768-montelukast-sodium-chemical-structure-drK1lRHjspWQ7613gJoZ.svg

Common Questions

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