Pactorin Retard 2.6 mg (Retard Tablet)

Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Nitroglycerin tablet
Company Aci limited

Indications

  • Prophylaxis of angina pectoris

Pharmacology

  • Causes relaxation of vascular smooth muscle
  • Produces vasodilator effect on peripheral arteries and veins
  • Reduces left ventricular end-diastolic pressure
  • Reduces systemic vascular resistance and arterial pressure

Dosage & Administration

  • Dosage should be adjusted according to individual patient response
  • Adult dosage: one Nitroglycerin 2.6 mg sustained released tablet or capsule in morning and evening
  • To be taken empty stomach

Interaction

  • May increase antihypertensive properties of vasodilators, calcium antagonists, beta-adrenergic blockers
  • Concomitant use with tricyclic antidepressants and alcohol may cause high blood pressure
  • May cause fall in blood pressure when used with phosphodiesterase type 5 (PDE5) inhibitors
  • Decreases clearance and enhances hemodynamic effects when used with aspirin
  • May reduce the pharmacologic effects of heparin when used concomitantly
  • Increases the bioavailability of dihydroergotamine

Contraindications

  • Known hypersensitivity to nitroglycerin, other organic nitrates, or nitrites
  • Acute myocardial infarction
  • Marked anaemia
  • Head trauma
  • Cerebral haemorrhage
  • Closed angle glaucoma

Side Effects

  • Headache at the onset of treatment
  • Tachycardia
  • Postural hypotension and syncope
  • Cyanosis and methaemoglobinaemia

Pregnancy & Lactation

  • No evidence relating to safety in pregnancy and lactation
  • Should be administered to pregnant women and nursing mothers only if considered essential by the physician

Precautions & Warnings

  • Use with caution in patients predisposed to closed-angle glaucoma
  • Abrupt discontinuation may lead to exacerbation of symptoms
  • Dosage should be reduced gradually over several days when discontinuing long term treatment
  • Particular attention required during early days of acute myocardial infarction

Overdose Effects

  • Peripheral vasodilation with fall in blood pressure and reflex tachycardia
  • Monitoring of cardiac function and general supportive measures should be used
  • Consider administration of vasopressors in life-threatening situations

Therapeutic Class

  • Nitrates: Coronary vasodilators

Storage Conditions

  • Store in a cool and dry place away from light and heat
  • Keep all medicines out of the reach of children

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