PruLax 2 mg (Tablet)
Unit Price: ৳ 24.00 (3 x 10: ৳ 720.00)
Strip Price: ৳ 240.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Prucalopride succinate |
| Company | Incepta pharmaceuticals ltd |
Indications
- Symptomatic treatment of chronic constipation in adults
Pharmacology
- Selective stimulator of 5-HT4 receptors
- No interaction with hERG channel or 5-HT1 receptors
- Stimulates motility by interacting specifically with 5-HT4 receptors in the GI tract
Dosage & Administration
- Adults: 2 mg once daily with or without food
- Older people: Start with 1 mg once daily; if needed, dose can be increased to 2 mg once daily
- Children: Not recommended for children and adolescents younger than 18 years
Interaction
- Low interaction potential with other medicinal products
- Not an inhibitor of P-gp at clinically relevant concentrations
- No clinically relevant effects on the pharmacokinetics of certain drugs
Contraindications
- Hypersensitivity to the active substance or excipients
- Renal impairment requiring dialysis
Side Effects
- Most frequently reported adverse reactions are headache and gastrointestinal symptoms
- Adverse reactions occur predominantly at the start of therapy and usually disappear within a few days with continued treatment
- Majority of adverse events were mild to moderate in intensity
Pregnancy & Lactation
- Not recommended during pregnancy
- Women of childbearing potential should use effective contraception
- Not recommended during breastfeeding based on animal studies
Precautions & Warnings
- Dose adjustment for severe renal impairment
- Caution in prescribing to patients with severe hepatic impairment
- Possible reduced efficacy of oral contraceptives during severe diarrhea
- Contains lactose, not recommended for patients with rare hereditary problems of galactose intolerance
Use in Special Populations
- Dose adjustment needed for severe renal impairment
- Start with 1 mg once daily for severe hepatic impairment (Child-Pugh class C)
- No dose adjustment required for mild to moderate renal or hepatic impairment
Overdose Effects
- Symptoms may include headache, nausea, and diarrhea
- No specific treatment available for overdose
- Supportive measures may be required for extensive fluid loss by diarrhea or vomiting
Therapeutic Class
- Osmotic purgatives
Storage Conditions
- Store at room temperature, below 30°C
- Dispense in original bottle and do not remove desiccant