Rabe 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (6 x 10: ৳ 480.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Aristopharma ltd
Also available as
Rabe 20 mg tablet

Title

Rabe Gastro-resistant tablets

Categories

  • Medicine
  • Gastroenterology

Description

Rabe Gastro-resistant tablets are used for the treatment of active duodenal ulcer, active benign gastric ulcer, symptomatic erosive or ulcerative gastro-esophageal reflux disease, GERD long-term management, Zollinger-Ellison Syndrome, and the eradication of Helicobacter pylori in patients with peptic ulcer disease.

Dosage form

Tablet

Dosage strength

20 mg

Indication

  • Duodenal ulcer
  • Gastric ulcer
  • GERD
  • Zollinger-Ellison Syndrome
  • H. pylori infection

Pharmacology

Rabeprazole suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase at the secretory surface of the gastric parietal cell.

Recommended dosage

  • Active duodenal ulcer and active benign gastric ulcer: 20 mg once daily in the morning
  • Erosive or ulcerative gastro esophageal reflux disease: 20 mg once daily for 4-8 weeks
  • Gerd maintenance: 20 mg or 10 mg once daily, depending upon patient response
  • Zollinger ellison syndrome: 60 mg once a day, may be titrated upwards to 120 mg/day based on individual patient needs
  • Pediatric patients 1 to 11 years:
    • Less than 15 kg: 5 mg once daily
    • 15 kg or more: 10 mg once daily
  • H pylori eradication: Rabeprazole sodium 20 mg twice daily, clarithromycin 500 mg twice daily, and amoxicillin 1g twice daily for 7 days

Administration

Should be taken in the morning, before eating, and swallowed whole without chewing or crushing.

Interactions

  • Ketoconazole
  • Itraconazole
  • Antifungal plasma levels
  • Liquid antacids
  • Atazanavir

Contraindications

  • Hypersensitivity to the active substance or to any of the excipients
  • Pregnancy
  • Breastfeeding

Side effects

  • Headache
  • Diarrhoea
  • Abdominal pain
  • Vomiting
  • Constipation
  • Dry mouth
  • Muscle pain
  • Drowsiness
  • Dizziness

Pregnancy category

Category C

Precautions and warnings

  • Gastric or oesophageal malignancy: Possibility of malignancy should be excluded prior to commencing treatment
  • Long term treatment: Patients treated for more than a year should be kept under regular surveillance
  • Fracture risk: May modestly increase the risk of hip, wrist, and spine fracture, predominantly in the elderly or with other recognized risk factors
  • Hypersensitivity reactions: Risk of cross-hypersensitivity reactions with other proton pump inhibitors
  • Blood dyscrasias: Post-marketing reports of thrombocytopenia and neutropenia
  • Hepatic enzyme abnormalities: Seen in clinical trials and reported since market authorization
  • Hypomagnesaemia: Severe hypomagnesaemia reported in patients treated with PPIs for at least three months, monitoring recommended
  • Vitamin B12 absorption: May reduce the absorption of vitamin B12
  • Subacute cutaneous lupus erythematosus: Associated with very infrequent cases of SCLE
  • Interference with laboratory tests: Increased Chromogranin A (CgA) level may interfere with investigations for neuroendocrine tumors
  • Renal and hepatic impairment: No dosage adjustment necessary

Use in special populations

  • Renal and hepatic impairment: No dosage adjustment necessary
  • Pediatric use: Not recommended

Overdose effects

Effects are generally minimal, reversible without further medical intervention, and no specific antidote is known.

Therapeutic class

Proton Pump Inhibitor

Storage conditions

Keep below 30°C, away from light and moisture, and out of the reach of children

Chemical structure

  • Molecular formula: C18H21N3O3S
  • Chemical image url: https://medex.com.bd/storage/res/g-res-942-rabeprazole-sodium-chemical-structure-atwg0Q4PlndQZhOY9GHX.svg

Common questions

  • What is it: Rabe 20 mg Capsule is a proton pump inhibitor (PPI) that suppresses gastric acid secretion.
  • Uses: Treatment of Duodenal ulcer, Gastric ulcer, GERD, Zollinger-Ellison Syndrome, Helicobacter pylori eradication
  • Side effects:
    • Diarrhea
    • Constipation
    • Nausea
    • Vomiting
    • Headache
    • Dizziness
    • Rash
    • Dry mouth
  • How to take: Should be taken with food, and the usual dose is one tablet once a day
  • Pregnancy and breastfeeding: Not recommended
  • Overdose: Call the doctor or Poison Control Center immediately
  • Duration of treatment: Depends on the condition being treated

Related Brands