Domfix 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 35.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Osl pharma limited
Also available as
Domfix 10 mg tablet Domfix 5 mg pediatric drop

Title

Domfix 5 mg/5 ml Suspension

Categories

  • Medicine
  • Gastrointestinal Health
  • Nausea and Vomiting Relief

Description

Domfix 5 mg/5 ml Suspension is a dopamine antagonist medication that is used to treat nausea and vomiting. It is also indicated for dyspeptic symptom complex, acute nausea and vomiting, Parkinson's disease, and for speeding barium transit in follow-through radiological studies.

Indications

  • Dyspeptic symptom complex
  • Delayed gastric emptying
  • Gastroesophageal reflux
  • Esophagitis
  • Upper abdominal pain
  • Eructation
  • Flatulence
  • Early satiety
  • Nausea and vomiting
  • Heartburn
  • Non-ulcer dyspepsia
  • Acute nausea and vomiting
  • Functional nausea and vomiting
  • Organic nausea and vomiting
  • Infectious nausea and vomiting
  • Nausea and vomiting induced by radiotherapy
  • Nausea and vomiting induced by drug therapy
  • Nausea and vomiting induced in migraine
  • Parkinson's disease
  • Dopamine-agonist induced nausea and vomiting
  • Radiological studies

Pharmacology

Domperidone is a dopamine antagonist that blocks dopamine receptors located in the Chemoreceptor Trigger Zone (CTZ) and stomach. It restores normal motility and tone of the upper gastrointestinal tract, facilitates gastric emptying, enhances antral and duodenal peristalsis, regulates contraction of the pylorus, increases esophageal peristalsis and lower esophageal sphincter pressure, and prevents regurgitation of gastric content.

DosageAndAdministration

  • Adults: 10-20 mg (1-2 tablets or 10-20 ml suspension), every 6-8 hours daily
  • Children: 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight, every 6-8 hours daily
  • AdministrationTiming: 15-30 minutes before meals

Interactions

  • Anticholinergic drugs
  • Antacids
  • Antisecretory drugs
  • CYP3A4 inhibitors
  • Neuroleptics
  • Dopaminergic agonists
  • Orally administered drugs

Contraindications

  • Known hypersensitivity to domperidone
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction
  • Perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

SideEffects

  • Transient intestinal cramps
  • Extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Neuroendocrinological phenomena
  • Galactorrhea
  • Gynecomastia
  • Allergic reactions such as rash and urticaria

PregnancyAndLactation

  • Pregnancy: Use during the first trimester justified by therapeutic benefit
  • Lactation: Not recommended unless benefits outweigh potential risk

PrecautionsAndWarnings

  • Caution in children
  • Increased risk of extrapyramidal reactions in young children
  • Hepatic impairment

UseInSpecialPopulations

  • Infants with caution and under close medical supervision

OverdoseEffects

  • Drowsiness
  • Disorientation
  • Extrapyramidal reactions

TherapeuticClass

Motility Stimulants/Dopamine antagonist

StorageConditions

Store below 30°C, Protected from light & moisture. Keep out of children's reach.

ChemicalStructure

  • MolecularFormula: C22H24ClN5O2
  • ChemicalStructureImageURL: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg

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