Dexatab 0.5 mg (Tablet)
Unit Price: ৳ 1.00 (25 x 10: ৳ 250.00)
Strip Price: ৳ 10.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Dexamethasone |
| Company | Renata limited |
| Also available as |
Indications
- Control of severe or incapacitating allergic conditions
- Treatment of collagen diseases like lupus erythematosus and rheumatoid arthritis
- Management of dermatologic diseases such as bullous dermatitis herpetiformis, exfoliative erythroderma, and pemphigus
- Endocrine disorders control
- Management of gastrointestinal diseases like regional enteritis and ulcerative colitis
- Treatment of hematologic disorders such as acquired hemolytic anemia and idiopathic thrombocytopenic purpura
- Use in neoplastic diseases like leukemias and lymphomas
- Treatment of nervous system conditions including acute exacerbations of multiple sclerosis
- Ophthalmic diseases management
- Renal diseases treatment such as idiopathic nephrotic syndrome
- Management of respiratory diseases like berylliosis, tuberculosis, and eosinophilic pneumonias
- Adjunctive therapy for rheumatic disorders
- Diagnostic testing of adrenocortical hyperfunction
Pharmacology
- Synthetic glucocorticoid
- Decreases inflammation by inhibiting leukocyte migration
- Reversal of increased capillary permeability
- Suppression of normal immune response
Dosage & Administration
- Oral dosages vary from 1 mg to 10 mg for adults
- Oral dosages vary from 0.03-0.20 mg/kg body weight for children
- Intravenous, intramuscular, or local injection administration
- Systemic therapy dosage in adults typically 0.05-0.20 mg/kg body weight
Interaction
- Enhanced potassium loss with diuretics and/or cardiac glycosides
- Impaired glucose tolerance with antidiabetics
- Increased risk of gastrointestinal ulceration with non-steroidal anti-inflammatory drugs
- Alteration of oral anticoagulant needs
- Decreased effectiveness with liver enzyme inducing drugs
Contraindications
- Gastric and duodenal ulcers
- Systemic and ophthalmic fungal infections
- Viral infections such as varicella and herpes genitalis
- Glaucoma
- Hypersensitivity to corticosteroids
Side Effects
- Cushing-like syndrome
- Fluid and electrolyte disturbances
- Musculo-skeletal effects including myopathy and osteoporosis
- Gastro-intestinal effects such as ulceration and haemorrhage
- Dermatological effects like skin atrophy and striae
- Central Nervous System effects including convulsions and pseudotumor cerebri
- Ophthalmic effects such as glaucoma and cataracts
- Immunosuppressive effects leading to increased susceptibility to infections
Pregnancy & Lactation
- Pregnancy Category C
- Use during pregnancy justified by potential benefit vs. potential risk
- Corticosteroids appear in breast milk
- Mothers taking high dosages advised not to breast-feed
Precautions & Warnings
- Use of lowest possible dose
- Caution in patients with congestive heart failure, hypertension, or renal insufficiency
- Minimize drug-induced secondary adrenocortical insufficiency
- Caution in active or latent peptic ulcers and gastrointestinal conditions
- Consideration for patients at increased risk of osteoporosis before initiating therapy
- Caution with high doses in patients with myasthenia gravis or receiving neuromuscular blocking drugs
Use in Special Populations
- Titration to lowest effective dose in pediatric patients
Overdose Effects
- Treatment by supportive and symptomatic therapy
Storage Conditions
- Tablet storage in cool & dry place protected from light & moisture
- Injection storage below 30°C, protected from light, and not frozen