Glinta-M 2.5 mg+500 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Renata limited |
| Also available as |
Therapeutic Class
- Combination Oral hypoglycemic preparations
Indications
- Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus
Pharmacology
- Inhibitor of DPP-4 (dipeptidyl peptidase-4) enzyme
- Increases concentrations of active incretin hormones
- Stimulates release of insulin from pancreatic beta cells
- Decreases secretion of glucagon from pancreatic alpha cells
- Lowers both basal and postprandial plasma glucose
- Decreases hepatic glucose production
- Improves insulin sensitivity
Dosage & Administration
- Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
- Individualized dosage based on effectiveness and tolerability
- Gradual dose escalation to reduce gastrointestinal side effects
- Recommended starting dose for different patient groups
Interaction
- Potential interaction with cationic drugs
- Potential for metabolic acidosis with carbonic anhydrase inhibitors
- Effect of inducers of P-glycoprotein and CYP3A4 enzymes on Linagliptin
- Drugs affecting glycemic control
Contraindications
- Contraindicated in patients with renal impairment
- Contraindicated in acute or chronic metabolic acidosis
- Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Most common side effects are nasopharyngitis and diarrhea
- Hypoglycemia more common in patients treated with sulfonylureas
Pregnancy & Lactation
- Caution advised during pregnancy and lactation due to lack of adequate studies in pregnant women
Precautions & Warnings
- Discontinue drug immediately in case of lactic acidosis or suspected pancreatitis
- Monitor Vitamin B12 levels annually
- Symptoms and precautions for lactic acidosis
- Instructions for alcohol consumption, other medicines, counseling, travel, and emergency
- Risk of hypoglycemia with the combination
- Importance of recognizing symptoms of low blood sugar
Overdose Effects
- Usual supportive measures in case of overdose
- Removal of Metformin Hydrochloride by dialysis
- No dose-related clinical adverse drug reactions with Linagliptin
- Reported hypoglycemia and lactic acidosis in Metformin Hydrochloride overdose cases
Drug Storage Conditions
- Keep in a cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of the reach of children
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