Niloren 200 mg (Capsule)
Unit Price: ৳ 800.00 (2 x 6: ৳ 9,600.00)
Strip Price: ৳ 4,800.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Nilotinib |
| Company | Renata limited |
Indications
- Treatment of newly diagnosed adult patients with Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in chronic phase
- Treatment of chronic phase (CP) and accelerated phase (AP) Ph+ CML in adult patients resistant to or intolerant to prior therapy
Pharmacology
- Inhibition of the tyrosine kinase activity of the BCR-ABL protein
- Inhibits TEL-platelet-derived growth factor receptor-beta (TEL-PDGFRbeta) and FIP1-like-1-PDGFRalpha
- Inhibition of the c-Kit receptor kinase
Dosage & Administration
- Recommended Dose: Newly diagnosed Ph+ CML-CP: 300 mg orally twice daily
- Resistant or intolerant Ph+ CML-CP and CML-AP: 400 mg orally twice daily
- Administer Nilotinib approximately 12 hours apart and must not take with food
Interaction
- Drugs that inhibit gastric acid secretion may reduce solubility and bioavailability of Niloren
Contraindications
- Hypokalaemia, hypomagnesaemia, long QT syndrome
- Concomitant use with potent CYP3A4 inhibitors or antiarrhythmics and other QT prolonging drugs
- Concomitant use with potent CYP3A4 inducers
Side Effects
- Rash, pruritus, hepatotoxicity
- Headache, fever, GI disturbances
- Alopecia, asthenia, muscle spasms
- Myelosuppression, thrombotic disorders or haemorrhage
- Arrhythmias, heart failure, pericarditis
Pregnancy & Lactation
- Pregnancy Category D
- Sexually active female patients should use effective contraception during treatment
- Should not breast-feed
- No data to support use in pediatrics
Precautions & Warnings
- History of pancreatitis, total gastrectomy
- Hepatic impairment
- Maintain adequate hydration and correct electrolyte imbalances prior to therapy
Overdose Effects
- Symptoms: Neutropenia, vomiting and drowsiness
- Management: Monitor patient and give supportive treatment
Therapeutic Class
- Targeted Cancer Therapy
Storage Conditions
- Store in a cool (not above 30°C) and dry place, away from light
- Keep out of the reach of children