Dial 60 mg (Tablet)
Unit Price: ৳ 3.80 (10 x 10: ৳ 380.00)
Strip Price: ৳ 38.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Diltiazem hydrochloride |
| Company | Nipa pharmaceuticals ltd |
Indications
- Prophylaxis of chronic stable and vasopastic angina pectoris
- Treatment of myocardial infarction
- Management of hypertension
- Treatment of arrhythmias
- Management of Raynaud's phenomenon
- Treatment of oesophageal motility disorder
- Management of migraine
Pharmacology
- Calcium channel antagonist
- Peripheral and coronary vasodilator
- Negative inotropic activity
- Inhibits cardiac conduction at sino-atrial and atrioventricular nodes
- Direct dilatation of coronary arteries and arterioles
- Reduces oxygen requirements of myocardial tissues
- Reduces systemic pressure of cardiac 'after load'
- Slowed electrophysiological activity through the S-A and A-V nodes
- Reduces peripheral vascular resistance
- High protein binding
- Rapid absorption
- Metabolized in the liver
- Excreted through bile
Dosage & Administration
- Usual dose of 60 mg thrice daily for film-coated formulation
- Dosage may be increased to 180-300 mg/day if necessary
- Starting dose of 30 mg four times daily for film-coated formulation
- Divided doses may be increased at 1 to 2 days intervals
- Higher doses up to 480 mg/day used for unstable angina
- Starting dose of 60 mg twice daily for elderly and patients with impaired hepatic or renal function
- Starting dose of 90 mg or 120 mg twice daily for mild to moderate hypertension sustained release formulation
- Up to 360 mg daily may be required for hypertension sustained release formulation
- Starting dose of 90 mg or 120 mg twice daily for angina sustained release formulation
Interaction
- Concomitant prophylactic therapy with short- or long-acting nitrates may be administered safely during diltiazem therapy
- Recommended caution and careful dosage titration with other drugs affecting cardiac contractility or conduction
Contraindications
- Hypersensitivity to the drug
- Sick sinus syndrome
- Second or third degree AV block
- Severe hypertension
- Acute myocardial infarction
- Radiographically documented pulmonary congestion
Side Effects
- Bradycardia
- Sino-atrial block
- Atrioventricular block
- Hypertension
- Malaise
- Headache
- Hot flushes
- GIT disturbances
- Oedema
- Hepatitis
- Depression
Pregnancy & Lactation
- No adequate and controlled studies in pregnant women
- Use during pregnancy only when potential benefits justify possible risk to the fetus
- Distributed into milk
- Women receiving the drug should not breastfeed their infants
- Use alternative method of infant feeding if diltiazem therapy is considered necessary in nursing women
Therapeutic Class
- Calcium-channel blockers
Storage Conditions
- Keep medicine out of the reach of children
- Store in a cool and dry place