Litizem 30 mg (Tablet)

Indications

• Prophylaxis of chronic stable and vasospastic angina pectoris
• Treatment of hypertension
• Management of myocardial infarction
• Treatment of coronary artery spasm
• Management of arrhythmias
• Treatment of Raynaud's phenomenon
• Management of oesophageal motility disorder
• Treatment of migraine

Mode of Action

• Calcium channel antagonist
• Peripheral and coronary vasodilator
• Negative inotropic activity
• Inhibition of cardiac conduction
• Reduction of systemic pressure
• Reduction of oxygen requirements
• Reduction of peripheral vascular resistance

Dosage & Administration

• Usual dose of 60 mg thrice daily for film-coated tablet
• Possible increase to 180-300 mg/day for individual patients
• Starting dose of 60 mg twice daily for elderly or patients with impaired hepatic or renal function
• Initial dose of 90 mg or 120 mg twice daily for sustained release formulation
• Up to 360 mg daily required for hypertension in some cases

Interaction

• Concomitant therapy with short-or long-acting nitrates
• Careful dosage titration with other drugs affecting cardiac contractility or conduction

Contraindications

• Known hypersensitivity to the drug
• Sick sinus syndrome
• Second or third degree AV block
• Severe hypertension
• Acute myocardial infarction
• Radiographically documented pulmonary congestion

Side Effects

• Bradycardia
• Sino-atrial block
• Atrioventricular block
• Hypertension
• Malaise
• Headache
• Hot flushes
• GIT disturbances
• Oedema
• Hepatitis
• Depression

Pregnancy & Lactation

• Use during pregnancy when potential benefits justify possible risk to fetus
• Drug distribution into milk
• Need for alternative method of infant feeding if diltiazem therapy is considered necessary in nursing women

Therapeutic Class

Calcium-channel blockers

Storage Conditions

Keep out of reach of children. Store in a cool and dry place.

Related Brands

• Litizem 60 mg (Tablet) - incepta-pharmaceuticals-ltd
• Diltiazem 60 mg (Tablet) - albion-laboratories-limited