Litizem 60 mg (Tablet)

Unit Price: ৳ 3.80 (10 x 10: ৳ 380.00)
Strip Price: ৳ 38.00

Medicine Details

Category Details
Generic Diltiazem hydrochloride
Company Incepta pharmaceuticals ltd
Also available as
Litizem 30 mg tablet

Title

Litizem Film-coated Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

Litizem film-coated tablet is used for the prophylaxis and treatment of chronic stable (classical) and vasospastic angina pectoris, hypertension, myocardial infarction, coronary artery spasm, arrhythmias, Raynaud's phenomenon, oesophageal motility disorder, and migraine.

Dosage formulation

Film-coated

Dosage administration

  • Usual dose: 60 mg thrice daily
  • Dosage may vary based on individual response
  • Dosage range: 60-300 mg/day
  • Higher doses up to 480 mg/day beneficial in unstable angina
  • Elderly and patients with impaired hepatic or renal function: Recommended starting dose is 60 mg twice daily

Interaction

Concomitant prophylactic therapy with short- or long-acting nitrates may be administered safely during diltiazem therapy. Caution when administered with drugs affecting cardiac contractility and/or conduction.

Contraindications

  • Known hypersensitivity to the drug
  • Sick sinus syndrome
  • Second or third degree AV block
  • Severe hypertension
  • Acute myocardial infarction
  • Radiographically documented pulmonary congestion

Side effects

  • Bradycardia
  • Sino-atrial block
  • Atrioventricular block
  • Hypertension
  • Malaise
  • Headache
  • Hot flushes
  • GIT disturbances
  • Oedema
  • Hepatitis
  • Depression

Pregnancy lactation

No adequate and controlled studies to date. Use during pregnancy when benefits justify potential risks. Distributed into milk, nursing women should avoid breastfeeding.

Therapeutic class

Calcium-channel blockers

Storage conditions

Keep out of reach of children. Store in a cool and dry place.

Pharmacology

  • Mechanism of action: Calcium channel antagonist
  • Actions:
    • Antianginal: Dilates coronary arteries and arterioles, increasing oxygen supply to myocardial tissues. Reduces systemic pressure of cardiac 'afterload'.
    • Antiarrhythmic: Slows electrophysiological activity at the sino-atrial and atrioventricular nodes.
    • Antihypertensive: Reduces peripheral vascular resistance through vasodilation.
  • Absorption: Rapid (>90% oral dose)
  • Protein binding: Very high
  • Metabolism excretion: Metabolized in liver, excreted (60%) through bile

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