Diltiazem 60 mg (Tablet)

Title

• Diltiazem Film-Coated Tablet
• Diltiazem Sustained Release Tablet

Categories

• Medicine
• Healthcare
• Pharmaceutical

Indications

• Prophylaxis and treatment of chronic stable and vasopastic angina pectoris
• Management of hypertension
• Myocardial infarction
• Coronary artery spasm
• Arrhythmias
• Raynaud's phenomenon
• Oesophageal motility disorder
• Migraine

Mode of Action

• Calcium channel antagonist
• Peripheral and coronary vasodilator
• Negative inotropic activity
• Inhibits cardiac conduction at the sino-atrial and atrioventricular nodes
• Direct dilatation of coronary arteries and arterioles
• Reduction of systemic pressure of cardiac afterload
• Slowed electrophysiological activity through the S-A and A-V nodes
• Reduction of peripheral vascular resistance

Dosage & Administration

• Film-coated formulation: Usual dose of 60 mg thrice daily
• Film-coated formulation: Dose may be increased to 180-300 mg/day
• Sustained release formulation: Initial dose for mild to moderate hypertension - 90 mg or 120 mg twice daily
• Sustained release formulation: Initial dose for angina - 90 mg or 120 mg twice daily

Interaction

• Concomitant prophylactic therapy with short- or long-acting nitrates
• Caution and careful dosage titration with other drugs affecting cardiac function

Contraindications

• Known hypersensitivity to the drug
• Sick sinus syndrome
• Second or third degree AV block
• Severe hypertension
• Acute myocardial infarction
• Radiographically documented pulmonary congestion

Side Effects

• Bradycardia
• Sino-atrial block
• Atrioventricular block
• Hypertension
• Malaise
• Headache
• Hot flushes
• GIT disturbances
• Oedema
• Hepatitis
• Depression

Pregnancy & Lactation

• Use during pregnancy when potential benefits justify possible risk to fetus
• Avoid breastfeeding while on diltiazem therapy

Therapeutic Class

• Calcium-channel blockers

Storage Conditions

• Store in a cool and dry place

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