Livcare 10 mg (Tablet)
Unit Price: ৳ 55.00 (1 x 10: ৳ 550.00)
Strip Price: ৳ 550.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Obeticholic acid |
| Company | Aristopharma ltd |
| Also available as |
Indications
- Treatment of adult patients with primary biliary cholangitis (PBC)
- Patients without cirrhosis
- Patients with compensated cirrhosis without evidence of portal hypertension
- In combination with ursodeoxycholic acid (UDCA) with inadequate response to UDCA
- Monotherapy in patients unable to tolerate UDCA
Pharmacology
- Mechanism of action: Obeticholic acid is an agonist for Farnesoid X Receptor (FXR)
- Key regulator of bile acid, inflammatory, fibrotic and metabolic pathways
- Decreases intracellular hepatocyte concentrations of bile acids
- Increases transport of bile acids out of the hepatocytes
- Promotes choleresis, reducing hepatic exposure to bile acids
- Pharmacodynamic markers: FGF-19 levels, cholic acid and chenodeoxycholic acid concentrations
- Cardiac Electrophysiology: Does not prolong QT interval
Dosage & Administration
- Recommended dosage regimen for PBC patients without cirrhosis or with compensated cirrhosis
- Important dosage and administration instructions
- Monitoring to assess safety and need for discontinuation
- Management of patients with intolerable pruritus
Interaction
- Bile Acid Binding Resins interaction
- Warfarin interaction
- CYP1A2 Substrates with Narrow Therapeutic Index interaction
- Inhibitors of Bile Salt Efflux Pump interaction
Contraindications
- Decompensated cirrhosis
- Compensated cirrhosis with evidence of portal hypertension
- Complete biliary obstruction
Side Effects
- Pruritus
- Fatigue
- Stomach pain and discomfort
- Rash
- Arthralgia
- Oropharyngeal pain
- Dizziness
- Constipation
- Abnormal thyroid function
- Eczema
Pregnancy & Lactation
- Limited human data on use during pregnancy
- No developmental abnormalities or fetal harm observed in animal studies
- Unknown presence in human milk
- Consideration of developmental and health benefits of breastfeeding
Precautions & Warnings
- Hepatic decompensation and failure in PBC patients with cirrhosis
- Severe pruritus
- Reduction in HDL-C
- Monitoring of serum lipid levels
Use in Special Populations
- Pediatric Use: Safety and effectiveness not established
- Geriatric Use: No overall differences in safety or effectiveness observed
- Hepatic Impairment: Contraindicated in patients with decompensated cirrhosis
Overdose Effects
- Dose-dependent increase in the incidence of hepatic adverse reactions
- Elevations in liver biochemical tests
- Ascites
- Jaundice
- Portal hypertension
- Supportive care administered as appropriate
Therapeutic Class
- Farnesoid X Receptor Agonists
Storage Conditions
- Store below 30°C in a dry place
- Protect from light
- Keep out of children's reach