Prebichol 10 mg (Tablet)
Unit Price: ৳ 55.00 (2 x 10: ৳ 1,100.00)
Strip Price: ৳ 550.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Obeticholic acid |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Primary biliary cholangitis treatment for adult patients
- Treatment for patients with or without cirrhosis
- Combination with ursodeoxycholic acid (UDCA)
- Monotherapy for patients unable to tolerate UDCA
Pharmacology
- Mechanism of action as Farnesoid X Receptor agonist
- Regulator of bile acid, inflammatory, fibrotic, and metabolic pathways
- Decreases intracellular hepatocyte concentrations of bile acids
- Promotes choleresis and reduces hepatic exposure to bile acids
- Increase in concentrations of FGF-19
- Reduction in concentrations of cholic acid and chenodeoxycholic acid
- Cardiac electrophysiology effects
Dosage & Administration
- Contraindications for patients with decompensated cirrhosis
- Recommended dosage regimen for different patient scenarios
- Monitoring for biochemical response and safety
- Management of patients with intolerable pruritus
- Dosage reduction and interruption strategies
Interaction
- Effects of bile acid binding resins on absorption and efficacy
- Interaction with warfarin and monitoring of INR
- Potential impact on CYP1A2 substrates with narrow therapeutic index
- Avoidance of inhibitors of bile salt efflux pump
Contraindications
- Contraindications for patients with decompensated cirrhosis or portal hypertension
- Contraindication for complete biliary obstruction
Side Effects
- Common side effects like pruritus, fatigue, stomach pain, and discomfort
- Less common side effects like rash, joint pain, oropharyngeal pain, dizziness, constipation, abnormal thyroid function, and eczema
Pregnancy & Lactation
- Limited human data on use during pregnancy
- No observed developmental abnormalities or fetal harm in animal studies
- Lack of information on presence in human milk and effects on breastfed infants
Precautions & Warnings
- Risk of hepatic decompensation and failure in PBC patients with cirrhosis
- Recognition and management of severe pruritus
- Potential reduction in HDL-C levels and monitoring for lipid level changes
Use in Special Populations
- Absence of established safety and effectiveness in pediatric patients
- Consideration of developmental and health benefits of breastfeeding
Overdose Effects
- Dose-dependent increase in hepatic adverse reactions at higher dosages
- Need for careful observation and supportive care in case of overdosage
Therapeutic Class
- Farnesoid X Receptor Agonists
Storage Conditions
- Store below 30°C in a dry place and protect from light