Prebichol 5 mg (Tablet)
Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)
Strip Price: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Obeticholic acid |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of primary biliary cholangitis (PBC) in adult patients
Pharmacology
- Mechanism of action as an agonist for Farnesoid X Receptor (FXR)
- Pharmacodynamic markers
- Cardiac electrophysiology
Dosage & Administration
- Dosage instructions
- Monitoring for safety and progression of PBC
- Management of intolerable pruritus
- Reduced dosage strategies
Interaction
- Interactions with bile acid binding resins
- Interaction with Warfarin
- Effect on CYP1A2 substrates
- Interaction with inhibitors of Bile Salt Efflux Pump (BSEP)
Contraindications
- Not recommended for patients with decompensated cirrhosis or portal hypertension
- Contraindicated in cases of complete biliary obstruction
Side Effects
- Common side effects such as pruritus, fatigue, stomach pain
- Other common side effects like rash, arthralgia, dizziness, constipation
Pregnancy & Lactation
- Limited human data on use during pregnancy
- No information on presence in human milk
- Consideration for breastfeeding mothers
Precautions & Warnings
- Risk of hepatic decompensation and failure in PBC patients with cirrhosis
- Management strategies for severe pruritus
- Reduction in HDL-C and monitoring of lipid levels
Use in Special Populations
- Safety and effectiveness in pediatric patients not established
- Consideration for geriatric use and hepatic impairment
Overdose Effects
- Dose-dependent increase in hepatic adverse reactions
- Observation and supportive care in case of overdosage
Therapeutic Class
- Farnesoid X Receptor Agonists
Storage Conditions
- Storage temperature and protection from light