Zerotil 125 mg/5 ml (Powder for Suspension)

70 ml bottle: ৳ 320.00

Medicine Details

Indications

  • Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
  • Acute Bacterial Otitis Media caused by Streptococcus pneumoniae
  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae
  • Lower respiratory tract infections including pneumoniae caused by Streptococcus pneumoniae
  • Secondary bacterial infections of Acute bronchitis caused by Streptococcus pneumoniae

Pharmacology

Broad-spectrum bactericidal activity against a wide range of common pathogens, including β-lactamase producing strains

Dosage

  • 250 mg b.i.d. for 5-10 days for Pharyngitis/tonsillitis in adolescents and adults
  • 20 mg/kg/day b.i.d for 5-10 days for Pharyngitis/Tonsillitis in Paediatric Patients
  • 750 mg three times daily by IM or IV injection for adults in severe infections

Administration

Freshly reconstituted solution is recommended and maintains potency for at least 24 hours at room temperature

Interaction

No potentially hazardous interactions reported

Contraindications

Contraindicated in patients with known allergy to Cephalosporins

Side Effects

  • Rashes
  • Gastrointestinal disturbances
  • Overgrowth of non susceptible organisms e.g. Candida with prolonged use

Pregnancy & Lactation

US FDA pregnancy category of Cefuroxime is B; caution should be exercised when administered to a nursing woman

Precautions & Warnings

  • Given with care to patients receiving concurrent treatment with potent diuretics & who has history of colitis
  • May be given safely to patients who are hypersensitive to penicillin although cross reactions have been reported

Therapeutic Class

Second generation Cephalosporins

Reconstitution

  • For 750 mg intramuscular injection: Add 3 ml water for injection to vial and then shake gently for dispersion
  • For 750 mg intravenous injection: Add 8 ml water for injection to vial and then shake gently for dispersion

Storage Conditions

Store in a cool, dry place (below 30<sup>o</sup> C), away from light & moisture

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