Presart HZ 40 mg+12.5 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Telmisartan hydrochlorothiazide |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of hypertension
- Lowering blood pressure
- Reduction of risk for cardiovascular events
- Can be used alone or with other antihypertensive agents
Pharmacology
- Telmisartan blocks vasoconstrictor and aldosterone-secreting effects of angiotensin II
- Action is independent of the pathways for angiotensin II synthesis
- Hydrochlorothiazide is a thiazide diuretic that affects renal tubular mechanisms of electrolyte reabsorption
- Reduces plasma volume and increases plasma renin activity and aldosterone secretion
Dosage & Administration
- Telmisartan monotherapy 80 mg once daily, can be titrated up to 160 mg/25 mg after 2 to 4 weeks
- Hydrochlorothiazide 25 mg once daily, can be titrated up to 160 mg/25 mg after 2 to 4 weeks
- May be administered with other antihypertensive drugs
Interaction
- Caution with concomitant use of aliskiren, digoxin, lithium, other medicines for high blood pressure, NSAIDs, corticosteroids, ACE blockers, and angiotensin II receptor blockers
- May interfere with certain laboratory tests, causing false results
Contraindications
- Contraindicated in patients with known hypersensitivity to Telmisartan, Hydrochlorothiazide, or any other component
- Do not co-administer with Aliskiren in patients with Diabetes
Side Effects
- Dizziness
- Drowsiness
- Tired feeling
- Flushing (warmth, redness, or tingly feeling)
- Back pain
- Nausea
- Diarrhea
- Stomach pain
- Allergy
- Fever
- Leg pain
- Chest pain
- Insomnia
- Somnolence
- Dry mouth
- Elevations of liver enzymes or serum bilirubin
- Leg cramps
- Myalgia
- Dermatitis
- Weakness
- Gastric irritation
- Photosensitivity
- Urticaria
- Muscle spasm
- Restlessness
Pregnancy & Lactation
- Pregnancy Category D
- Use during second and third trimesters reduces fetal renal function and increases morbidity and death
- Discontinue use when pregnancy is detected
- Presence in human milk not established, thiazides appear in human milk
Precautions & Warnings
- Caution in patients with kidney disease, liver disease, dehydration, untreated mineral imbalance, gout, or lupus
- Monitor blood sugar levels in diabetic patients
- Caution regarding body potassium levels and potassium supplements
- May cause dizziness; avoid driving or using machinery
- Report prolonged diarrhea or vomiting to the doctor
- Ensure adequate fluid intake to prevent dehydration
Use in Special Populations
- Safety and effectiveness not established in pediatric patients
- Cautious dose selection for elderly patients
- Initiate treatment under close medical supervision in patients with biliary obstructive disorders or hepatic insufficiency
- Not recommended in patients with severe renal impairment
Overdose Effects
- Manifestations may include hypertension, dizziness, tachycardia, hypokalemia, and dehydration
- Telmisartan not removed by hemodialysis
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Keep in a cool and dry place
- Protect from light
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